Small nucleolar RNA U6-53/MBII-28

In molecular biology, Small nucleolar RNA U6-53 (also known as MBII-28) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA U6-53/MBII-28
Predicted secondary structure and sequence conservation of snoU6-53
Identifiers
SymbolsnoU6-53
RfamRF00377
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

snoRNA U6-53 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

This snoRNA possesses sequence complementarity to U6 spliceosomal RNA and is likely to direct its 2'-O-methylation.[3]

References
  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Kiss T (April 2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145–8. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400. S2CID 8968788.
  3. Ganot P, Jády BE, Bortolin ML, Darzacq X, Kiss T (October 1999). "Nucleolar factors direct the 2'-O-ribose methylation and pseudouridylation of U6 spliceosomal RNA". Molecular and Cellular Biology. 19 (10): 6906–17. doi:10.1128/mcb.19.10.6906. PMC 84686. PMID 10490628.


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