Small nucleolar RNA SNORD88

In molecular biology, Small Nucleolar RNA SNORD88 (also known as HBII-180) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD88
Predicted secondary structure and sequence conservation of SNORD88
Identifiers
SymbolSNORD88
RfamRF00604
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

SNORD88 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the C/D box family function in directing site-specific 2′-O-methylation of substrate RNAs.[1] This snoRNA is the human orthologue of mouse snoRNA MBII-180.[2] SNORD88 is also related to mouse snoRNA MBII-211. SNORD88 is predicted to guide the 2′O-ribose methylation of 28S ribosomal RNA (rRNA) residue C3680.[3]

There is evidence that SNORD88 is processed into smaller fragments in a similar fashion to a microRNA and can suppress protein expression.[4][5]

References
  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2′-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
  3. Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158–162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
  4. Ono M, Yamada K, Avolio F, Scott MS, van Koningsbruggen S, Barton GJ, Lamond AI (May 2010). "Analysis of human small nucleolar RNAs (snoRNA) and the development of snoRNA modulator of gene expression vectors". Molecular Biology of the Cell. 21 (9): 1569–1584. doi:10.1091/mbc.E10-01-0078. PMC 2861615. PMID 20219969.
  5. Ono M, Scott MS, Yamada K, Avolio F, Barton GJ, Lamond AI (May 2011). "Identification of human miRNA precursors that resemble box C/D snoRNAs". Nucleic Acids Research. 39 (9): 3879–3891. doi:10.1093/nar/gkq1355. PMC 3089480. PMID 21247878.
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