Small nucleolar RNA SNORD83

In molecular biology, Small nucleolar RNA SNORD83 (also known as U83 and U84) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA SNORD83 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA SNORD83 are spliced from introns 5 and 4 of the BAT1 gene in mammals.[2][3]

Small nucleolar RNA SNORD83
Predicted secondary structure and sequence conservation of SNORD83
Identifiers
SymbolSNORD83
Alt. SymbolsU83
RfamRF00137
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

References
  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Jady BE, Kiss T (2000). "Characterisation of the U83 and U84 small nucleolar RNAs: two novel 2'-O-ribose methylation guide RNAs that lack complementarities to ribosomal RNAs". Nucleic Acids Res. 28 (6): 1348–54. doi:10.1093/nar/28.6.1348. PMC 111033. PMID 10684929.
  3. Duga S, Asselta R, Malcovati M, Tenchini ML, Ronchi S, Simonic T (2000). "The intron-containing L3 ribosomal protein gene (RPL3): sequence analysis and identification of U43 and of two novel intronic small nucleolar RNAs". Biochim Biophys Acta. 1490 (3): 225–36. doi:10.1016/S0167-4781(99)00237-7. PMID 10684968.


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