Small nucleolar RNA SNORD75

In molecular biology, Small Nucleolar RNA SNORD75 (also known as U75) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD75
Predicted secondary structure and sequence conservation of SNORD75
Identifiers
SymbolSNORD75
RfamRF00612
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

U75 (SNORD75) belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs.[1] The mouse snoRNA Z19 is orthologous to human U75. U75 is predicted to guide the 2′-O-ribose methylation of 28S ribosomal RNA (rRNA) residue C4032.[2] In humans U75 shares the same non-protein coding host gene (gas5) with 9 other snoRNAs (U44, U47, U74, U76, U77, U78, U79, U80 and U81).[3]

References
  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2′-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158–162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
  3. Smith CM, Steitz JA (December 1998). "Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes". Molecular and Cellular Biology. 18 (12): 6897–6909. doi:10.1128/mcb.18.12.6897. PMC 109273. PMID 9819378.
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