Integrin alpha 2

ITGA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AOX, 1DZI, 1V7P, 4BJ3
Identifiers
Aliases	ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2
External IDs	OMIM: 192974 MGI: 96600 HomoloGene: 1662 GeneCards: ITGA2
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	53,094,779 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	115,068,636 bp[2]
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; islet of Langerhans; ; visceral pleura; ; seminal vesicula; ; vulva; ; urethra; ; cavity of mouth; ; stromal cell of endometrium; ; jejunal mucosa; ; lactiferous duct;
	Top expressed in
	cumulus cell; ; molar; ; blood; ; trigeminal ganglion; ; Paneth cell; ; left lung lobe; ; stellate reticulum; ; seminiferous tubule; ; pineal gland; ; stria vascularis;
	More reference expression data
	n/a
Gene ontology
Molecular function	collagen binding; virus receptor activity; protein-containing complex binding; collagen receptor activity; metal ion binding; integrin binding; protein binding; collagen binding involved in cell-matrix adhesion; protein heterodimerization activity; laminin binding; amyloid-beta binding; heparan sulfate proteoglycan binding;
Cellular component	axon terminus; integral component of membrane; cell projection; membrane; focal adhesion; basal part of cell; plasma membrane; cell surface; integrin complex; axon; integrin alpha2-beta1 complex; perinuclear region of cytoplasm; external side of plasma membrane; nucleus;
Biological process	positive regulation of collagen biosynthetic process; positive regulation of inflammatory response; response to hypoxia; positive regulation of phagocytosis, engulfment; skin morphogenesis; response to organic cyclic compound; collagen-activated signaling pathway; positive regulation of leukocyte migration; establishment of protein localization; positive regulation of transmission of nerve impulse; female pregnancy; cellular response to estradiol stimulus; cellular response to organic cyclic compound; hepatocyte differentiation; positive regulation of epithelial cell migration; blood coagulation; extracellular matrix organization; positive regulation of cell projection organization; response to L-ascorbic acid; wound healing; positive regulation of translation; substrate-dependent cell migration; mammary gland development; positive regulation of smooth muscle cell migration; focal adhesion assembly; cell-substrate adhesion; cellular response to mechanical stimulus; cell adhesion; response to parathyroid hormone; cell adhesion mediated by integrin; positive regulation of alkaline phosphatase activity; response to amine; hypotonic response; animal organ morphogenesis; mesodermal cell differentiation; integrin-mediated signaling pathway; positive regulation of collagen binding; viral entry into host cell; positive regulation of DNA binding; cell-matrix adhesion; cell population proliferation; viral process; positive regulation of smooth muscle contraction; response to muscle activity; positive regulation of cell adhesion; positive regulation of smooth muscle cell proliferation; positive regulation of positive chemotaxis; detection of mechanical stimulus involved in sensory perception of pain;
	Sources:Amigo / QuickGO
Orthologs
	3673
	16398
	ENSG00000164171
	ENSMUSG00000015533
	P17301
	Q62469
	NM_002203
	NM_008396
	NP_002194
	NP_032422
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.

The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.[5]

Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells.[6]

The DX5 monoclonal antibody recognizes mouse CD49b.[7]

Interactions

CD49b has been shown to interact with MMP1.[8][9]

References

GRCh38: Ensembl release 89: ENSG00000164171 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000015533 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".
Gagliani, Nicola; Magnani, Chiara F.; Huber, Samuel; Gianolini, Monica E.; Pala, Mauro; Licona-Limon, Paula; Guo, Binggege; Herbert, De'Broski R.; Bulfone, Alessandro (2013-06-01). "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells". Nature Medicine. 19 (6): 739–746. doi:10.1038/nm.3179. ISSN 1546-170X. PMID 23624599. S2CID 21305032.
Arase H, Saito T, Phillips JH, Lanier LL (August 2001). "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)". Journal of Immunology. 167 (3): 1141–4. doi:10.4049/jimmunol.167.3.1141. PMID 11466327.
Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001). "Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction". J. Biol. Chem. 276 (31): 29375–81. doi:10.1074/jbc.M102217200. PMID 11359774.
Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368–74. doi:10.1074/jbc.M104179200. PMID 11359786.

External links

CD49b+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha 2

External links

ITGA2 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
Human ITGA2 genome location and ITGA2 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164171 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015533 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".

[6] Gagliani, Nicola; Magnani, Chiara F.; Huber, Samuel; Gianolini, Monica E.; Pala, Mauro; Licona-Limon, Paula; Guo, Binggege; Herbert, De'Broski R.; Bulfone, Alessandro (2013-06-01). "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells". Nature Medicine. 19 (6): 739–746. doi:10.1038/nm.3179. ISSN 1546-170X. PMID 23624599. S2CID 21305032.

[pmid11466327-7] Arase H, Saito T, Phillips JH, Lanier LL (August 2001). "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)". Journal of Immunology. 167 (3): 1141–4. doi:10.4049/jimmunol.167.3.1141. PMID 11466327.

[pmid11359774-8] Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001). "Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction". J. Biol. Chem. 276 (31): 29375–81. doi:10.1074/jbc.M102217200. PMID 11359774.

[pmid11359786-9] Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368–74. doi:10.1074/jbc.M104179200. PMID 11359786.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Integrin alpha 2

Interactions

References

External links

Further reading

External links