CD96
CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene.[5] CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1).[6] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.[7]
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| Aliases | CD96, TACTILE, CD96 molecule | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606037 MGI: 1934368 HomoloGene: 68489 GeneCards: CD96 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].
References
- GRCh38: Ensembl release 89: ENSG00000153283 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000022657 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: CD96 molecule". Retrieved 2018-07-03.
- Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
- Martinet L, Smyth MJ (April 2015). "Balancing natural killer cell activation through paired receptors". Nature Reviews. Immunology. 15 (4): 243–254. doi:10.1038/nri3799. PMID 25743219. S2CID 20825600.
Further reading
- Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M (April 2004). "Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)". Journal of Immunology. 172 (7): 3994–3998. doi:10.4049/jimmunol.172.7.3994. PMID 15034010.
- Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, et al. (June 2007). "CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia". Proceedings of the National Academy of Sciences of the United States of America. 104 (26): 11008–11013. Bibcode:2007PNAS..10411008H. doi:10.1073/pnas.0704271104. PMC 1904175. PMID 17576927.
- Kaname T, Yanagi K, Chinen Y, Makita Y, Okamoto N, Maehara H, et al. (October 2007). "Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome". American Journal of Human Genetics. 81 (4): 835–841. doi:10.1086/522014. PMC 2227933. PMID 17847009.
- Meyer D, Seth S, Albrecht J, Maier MK, du Pasquier L, Ravens I, et al. (January 2009). "CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains". The Journal of Biological Chemistry. 284 (4): 2235–2244. doi:10.1074/jbc.M807698200. PMID 19056733.
- Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, et al. (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity. 11 (3): 232–238. doi:10.1038/gene.2010.1. PMID 20237496.
- Wu Y, Xiao M, Zhu L, Zhou XX, Gong Q, Xin X, et al. (June 2011). "[CD96 expression on bone marrow mononuclear cells in 91 patients with acute leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi (in Chinese). 19 (3): 585–588. PMID 21729528.
- Mohseni Nodehi S, Repp R, Kellner C, Bräutigam J, Staudinger M, Schub N, et al. (2012). "Enhanced ADCC activity of affinity maturated and Fc-engineered mini-antibodies directed against the AML stem cell antigen CD96". PLOS ONE. 7 (8): e42426. Bibcode:2012PLoSO...742426M. doi:10.1371/journal.pone.0042426. PMC 3411760. PMID 22879978.
- Eriksson EM, Keh CE, Deeks SG, Martin JN, Hecht FM, Nixon DF (2012). "Differential expression of CD96 surface molecule represents CD8⁺ T cells with dissimilar effector function during HIV-1 infection". PLOS ONE. 7 (12): e51696. Bibcode:2012PLoSO...751696E. doi:10.1371/journal.pone.0051696. PMC 3521672. PMID 23272144.
- Chávez-González A, Dorantes-Acosta E, Moreno-Lorenzana D, Alvarado-Moreno A, Arriaga-Pizano L, Mayani H (May 2014). "Expression of CD90, CD96, CD117, and CD123 on different hematopoietic cell populations from pediatric patients with acute myeloid leukemia". Archives of Medical Research. 45 (4): 343–350. doi:10.1016/j.arcmed.2014.04.001. PMID 24751333.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.