Integrin alpha-1
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.[5]
CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.[6] It has been shown to affect the motility of T cells.[7]
References
- GRCh38: Ensembl release 89: ENSG00000213949 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000042284 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Gardner, Humphrey (2014). "Integrin α1β1". I Domain Integrins. Advances in Experimental Medicine and Biology. 819: 21–39. doi:10.1007/978-94-017-9153-3_2. ISBN 978-94-017-9152-6. PMID 25023165.
- Reilly, Emma C.; Sportiello, Mike; Emo, Kris Lambert; Amitrano, Andrea M.; Jha, Rakshanda; Kumar, Ashwin B. R.; Laniewski, Nathan G.; Yang, Hongmei; Kim, Minsoo; Topham, David J. (9 September 2021). "CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection". Frontiers in Immunology. 12: 728669. doi:10.3389/fimmu.2021.728669. PMC 8462271. PMID 34566986.
- Reilly, EC; Lambert Emo, K; Buckley, PM; Reilly, NS; Smith, I; Chaves, FA; Yang, H; Oakes, PW; Topham, DJ (2 June 2020). "T(RM) integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection". Proceedings of the National Academy of Sciences of the United States of America. 117 (22): 12306–12314. doi:10.1073/pnas.1915681117. PMC 7275699. PMID 32439709.
Further reading
- Virtanen I, Korhonen M, Kariniemi AL, et al. (1991). "Integrins in human cells and tumors". Cell Differ. Dev. 32 (3): 215–27. doi:10.1016/0922-3371(90)90034-T. PMID 2099238.
- Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis". Atherosclerosis. 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
- Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture". J. Cell Sci. 103 (1): 267–71. doi:10.1242/jcs.103.1.267. PMID 1429908.
- Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line". J. Biol. Chem. 265 (11): 5938–41. doi:10.1016/S0021-9258(19)39269-5. PMID 1690718.
- Sonnenberg A, Linders CJ, Modderman PW, et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8". J. Cell Biol. 110 (6): 2145–55. doi:10.1083/jcb.110.6.2145. PMC 2116116. PMID 1693624.
- Belkin VM, Belkin AM, Dol'nikova AE, et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia. 56 (12): 2198–206. PMID 1807406.
- Bank I, Roth D, Book M, et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases". J. Clin. Immunol. 11 (1): 29–38. doi:10.1007/BF00918792. PMID 1827128. S2CID 6198792.
- Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium". J. Clin. Endocrinol. Metab. 71 (3): 645–9. doi:10.1210/jcem-71-3-645. PMID 2144294.
- Tawil NJ, Houde M, Blacher R, et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells". Biochemistry. 29 (27): 6540–4. doi:10.1021/bi00479a028. PMC 2710132. PMID 2169872.
- Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development". J. Cell Biol. 111 (5 Pt 1): 2159–70. doi:10.1083/jcb.111.5.2159. PMC 2116325. PMID 2229189.
- MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine". J. Clin. Pathol. 43 (4): 313–5. doi:10.1136/jcp.43.4.313. PMC 502365. PMID 2341567.
- Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239–43. Bibcode:1987PNAS...84.3239T. doi:10.1073/pnas.84.10.3239. PMC 304844. PMID 3033641.
- Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit". J. Biol. Chem. 262 (7): 3300–9. doi:10.1016/S0021-9258(18)61504-2. PMID 3546305.
- Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system". Exp. Cell Res. 221 (2): 478–85. doi:10.1006/excr.1995.1399. PMID 7493648.
- Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk". Immunol. Cell Biol. 72 (4): 306–13. doi:10.1038/icb.1994.46. PMID 7806264. S2CID 25016970.
- Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees". J. Histochem. Cytochem. 43 (4): 447–57. doi:10.1177/43.4.7897185. PMID 7897185.
- Pfaff M, Aumailley M, Specks U, et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp. Cell Res. 206 (1): 167–76. doi:10.1006/excr.1993.1134. PMID 8387021.
- Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit". J. Biol. Chem. 268 (4): 2989–96. doi:10.1016/S0021-9258(18)53871-0. PMID 8428973.
- Langholz O, Röckel D, Mauch C, et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins". J. Cell Biol. 131 (6 Pt 2): 1903–15. doi:10.1083/jcb.131.6.1903. PMC 2120685. PMID 8557756.
External links
- CD49a+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA1 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGA1 genome location and ITGA1 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha-1
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