S-14671

S-14671 is a naphthylpiperazine derivative which acts as a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8).[1][2] It displays only low and non-significant affinity for 5-HT1B and 5-HT3 sites.[2]

S-14671
Skeletal formula of S-14671
Space-filling model of the S-14671 molecule
Clinical data
ATC code
  • none
Identifiers
  • N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}thiophene-2-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H25N3O2S
Molar mass395.52 g·mol−1

In producing 5-HT1A-mediated effects such as hypothermia and spontaneous tail flicks in rodents, S-14671 is active at doses as low as 5 µg subcutaneously, and is about 10-fold more potent than 8-OH-DPAT and 100-fold more potent than flesinoxan and buspirone.[1][2] Other 5-HT1A-mediated effects of S-14671 include induction of flat-body posture, corticosterone secretion, inhibition of morphine-induced antinociception, and attenuation of the electrical activity of the dorsal raphe nucleus.[2]

S-14671 has been found to possess powerful efficacy in the rodent forced swim test and in the pigeon conflict test, indicating marked antidepressant and anxiolytic effects, respectively, of which are also 5-HT1A-mediated.[3][4] It has never been trialed in humans, perhaps due to its potency being too great.

See also

References
  1. Millan MJ, Canton H, Rivet JM, Lejeune F, Laubie M, Lavielle G (October 1991). "S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency". European Journal of Pharmacology. 203 (2): 319–22. doi:10.1016/0014-2999(91)90734-8. PMID 1839284.
  2. Millan MJ, Rivet JM, Canton H, et al. (August 1992). "S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors". The Journal of Pharmacology and Experimental Therapeutics. 262 (2): 451–63. PMID 1323650.
  3. Schreiber R, Brocco M, Gobert A, Veiga S, Millan MJ (December 1994). "The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists". European Journal of Pharmacology. 271 (2–3): 537–41. doi:10.1016/0014-2999(94)90816-8. PMID 7705455.
  4. Schreiber R, Brocco M, de Ladonchamps BL, Millan MJ (1995). "Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test". Pharmacology Biochemistry and Behavior. 51 (2–3): 211–5. doi:10.1016/0091-3057(94)00421-E. PMID 7667330. S2CID 32099533.
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