HLA-B44

HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.[1]


HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B44
Alleles	B*4401, 4402, 4403 . .
Structure (See HLA-B)
Shared data
Locus	chr.6 6p21.31

B44 is a split antigen of the broad antigen B12, and is a sister type of B45.

Serotype

Serotypes B44, B12, and B45 recognition of the
HLA B*44 gene products[2]
B*44	B44	B12	B45	Sample
allele	%	%	%	size (N)
*4402	98			6959
*4403	94			2854
*4404	65			42
*4405	92			130
*4406	44			9
B4401 was shown to be B4402 after errors corrected.
Alleles link-out to IMGT/HLA Database at EBI

Alleles

Disease

HLA-B44 increases recurrent sinopulmonary infections.[3] Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia).[4] B44 may be a cofactor in ankylosing spondylitis[5]

References

Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
derived from IMGT/HLA
Johnston DT, Mehaffey G, Thomas J, et al. (June 2006). "Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)". Clin. Immunol. 119 (3): 346–50. doi:10.1016/j.clim.2006.02.001. PMID 16542878.
Vacek MM, Schäffer AA, Davis J, et al. (January 2006). "HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia)". Clin. Immunol. 118 (1): 59–65. doi:10.1016/j.clim.2005.09.006. PMID 16257267.
Purrmann J, Zeidler H, Bertrams J, et al. (November 1988). "HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44". J. Rheumatol. 15 (11): 1658–61. PMID 3266250.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid15787720-1] Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.

[2] rived from IMGT/HLA

[pmid16542878-3] Johnston DT, Mehaffey G, Thomas J, et al. (June 2006). "Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)". Clin. Immunol. 119 (3): 346–50. doi:10.1016/j.clim.2006.02.001. PMID 16542878.

[pmid16257267-4] Vacek MM, Schäffer AA, Davis J, et al. (January 2006). "HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia)". Clin. Immunol. 118 (1): 59–65. doi:10.1016/j.clim.2005.09.006. PMID 16257267.

[pmid3266250-5] Purrmann J, Zeidler H, Bertrams J, et al. (November 1988). "HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44". J. Rheumatol. 15 (11): 1658–61. PMID 3266250.