HLA-B42
HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products.[1] HLA-B*4201 is common in Central Africa. (For terminology help see: HLA-serotype tutorial)
major histocompatibility complex (human), class I, B42 | ||
| Alleles | B*4201 B*4202 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*4201 | |
| EBI-HLA | B*4202 | |
| Locus | chr.6 6p21.31 | |
Serotype
| B*42 | B42 | other | Sample |
| allele | % | % | size (N) |
| 4201 | 93 | 2 | 1015 |
| 4202 | 95 | 80 |
Serological typing for B*4201 and B*4202 is relatively efficient.
B*4201 allele frequencies
| freq | ||
| ref. | Population | (%) |
| [3] | Zambia Lusaka | 14.8 |
| [3] | Mali Bandiagara | 13.8 |
| [3] | Burkina Faso Mossi | 13.2 |
| [3] | South African Natal Zulu | 12.0 |
| [3] | Burkina Faso Rimaibe | 9.6 |
| [3] | South Africa Tswana | 8.5 |
| [3] | Kenya Luo | 7.7 |
| [3] | Kenya | 7.3 |
| [3] | Kenya Nandi | 6.9 |
| [3] | Zimbabwe Harare Shona | 6.9 |
| [3] | Saudi Arabia | 5.6 |
| [3] | Cameroon Yaounde | 4.9 |
| [3] | Cameroon Beti | 4.0 |
| [3] | Cameroon Bamileke | 3.9 |
| [3] | Cameroon Sawa | 3.8 |
| [3] | Ivory Coast Akan Adiopodoume | 3.4 |
| [3] | Israel Gaza Palestinians | 2.4 |
| [3] | India North Delhi | 2.2 |
| [3] | Senegal Niokholo Mandenka | 1.6 |
| [3] | Mbenzele Pygmy (C. Afr. Rep.) | 1.5 |
| [3] | Iran Baloch | 1.5 |
| [3] | Pakistan Baloch | 1.5 |
| [3] | Sudanese | 1.5 |
| [3] | Tunisia | 1.5 |
| [3] | Pakistan Brahui | 1.4 |
| [3] | Cameroon Bamileke | 1.3 |
| [3] | Oman | 1.3 |
| [3] | Sudanese | 1.3 |
| [3] | Tunisia Tunis | 1.1 |
| [3] | Zimbabwe Harare Shona | 1.1 |
| [3] | Cameroon Bakola Pygmy | 1.0 |
| [3] | Pakistan Pathan | 1.0 |
| [3] | Portugal Centre | 1.0 |
| [3] | Saudi Arabia Guraiat and Hail | 1.0 |
| [3] | Morocco Casablanca | 0.9 |
| [3] | Senegal Dakar | 0.9 |
| [3] | Uganda Kampala | 0.9 |
| [3] | Cape Verde Southeastern Islands | 0.8 |
| [3] | Guinea Bissau | 0.8 |
| [3] | United Arab Emerates | 0.8 |
| [3] | Morocco Nador Metalsa Class I | 0.7 |
| [3] | Pakistan Karachi Parsi | 0.6 |
| [3] | Spain Majorca | 0.6 |
| [3] | China Yunnan Han pop2 | 0.5 |
| [3] | England Newcastle | 0.5 |
| [3] | Israel Arab Druse | 0.5 |
| [3] | Israel Jews | 0.5 |
| [3] | Italy Rome | 0.5 |
| [3] | Guadalajara Mestizos (2) (Mexico) | 0.5 |
| [3] | Morocco | 0.5 |
| [3] | Pakistan Sindhi | 0.5 |
| [3] | Senegal Niokholo Mandenka | 0.5 |
| [3] | Singapore Riau Malay | 0.5 |
References
- Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- derived from IMGT/HLA
- Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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