Arachidonyl-2'-chloroethylamide
Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the CB1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the CB2 (CB2R) (Ki = 1.4 nM for CB1R; Ki = 3100 nM for CB2R). [1]
Names | |
---|---|
Preferred IUPAC name
(5Z,8Z,11Z,14Z)-N-(2-Chloroethyl)icosa-5,8,11,14-tetraenamide | |
Other names
Arachidonyl-2'-chloroethylamide; ACEA | |
Identifiers | |
3D model (JSmol) |
|
ChEBI | |
ChEMBL | |
ChemSpider | |
PubChem CID |
|
CompTox Dashboard (EPA) |
|
| |
| |
Properties | |
C22H36ClNO | |
Molar mass | 365.99 g·mol−1 |
Solubility in other solvents | soluble in ethanol, chloroform, THF and DMSO |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
(what is ?)
Infobox references |
References
- Hillard, CJ; Manna, S; Greenberg, MJ; Dicamelli, R; Ross, RA; Stevenson, LA; Murphy, V; Pertwee, RG; Campbell, WB (1999). "Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)". The Journal of Pharmacology and Experimental Therapeutics. 289 (3): 1427–33. PMID 10336536.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.