VN1R4

Vomeronasal type-1 receptor 4 is a protein that in humans is encoded by the VN1R4 gene.[5][6]

VN1R4

Identifiers

VN1R4, V1RL4, vomeronasal 1 receptor 4

External IDs

MGI: 2159637 HomoloGene: 64475 GeneCards: VN1R4

Gene location (Human)

Chr.	Chromosome 19 (human)[1]

Band	19q13.42	Start	53,266,676 bp[1]
Band	19q13.42	End	53,267,723 bp[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)[2]

Band	17\|17 A3.2	Start	21,532,127 bp[2]
Band	17\|17 A3.2	End	21,535,174 bp[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

n/a

More reference expression data


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity pheromone receptor activity signal transducer activity pheromone binding
Cellular component	integral component of membrane plasma membrane membrane
Biological process	G protein-coupled receptor signaling pathway response to pheromone signal transduction sensory perception of chemical stimulus
Sources:Amigo / QuickGO

Species

Human

Mouse


317703


171234


ENSG00000228567


ENSMUSG00000058030


Q7Z5H5


Q8R296

RefSeq (mRNA)


NM_173857


NM_134200

RefSeq (protein)


NP_776256


NP_598961

Location (UCSC)

Chr 19: 53.27 – 53.27 Mb

Chr 17: 21.53 – 21.54 Mb

PubMed search

View/Edit Human

View/Edit Mouse

References

GRCh38: Ensembl release 89: ENSG00000228567 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000058030 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rodriguez I, Mombaerts P (Jul 2002). "Novel human vomeronasal receptor-like genes reveal species-specific families". Curr Biol. 12 (12): R409–11. doi:10.1016/S0960-9822(02)00909-0. PMID 12123587. S2CID 17013540.
"Entrez Gene: VN1R4 vomeronasal 1 receptor 4".

Further reading

Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang J, Webb DM (2003). "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8337–41. Bibcode:2003PNAS..100.8337Z. doi:10.1073/pnas.1331721100. PMC 166230. PMID 12826614.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRG (1 2 3 4 5 6 7)
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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