Tolufazepam

Tolufazepam is a drug that is a benzodiazepine derivative.[1] Studies have shown tolufazepam to have anticonvulsant and anxiolytic activity in animal subjects,[2] including convulsions elicited by pentylenetetrazol.[3]

Tolufazepam
Identifiers
  • 7-chloro-5-(2-chlorophenyl)-1-[2-(4-methylphenyl)sulfonylethyl]-3H-1,4-benzodiazepin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H20Cl2N2O3S
Molar mass487.40 g·mol−1
3D model (JSmol)
  • Clc2ccccc2C(=NCC1=O)c3cc(Cl)ccc3N1CCS(=O)(=O)c(cc4)ccc4C
  • InChI=1S/C24H20Cl2N2O3S/c1-16-6-9-18(10-7-16)32(30,31)13-12-28-22-11-8-17(25)14-20(22)24(27-15-23(28)29)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3 ☒N
  • Key:FFZOBTGTWSRRMB-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

See also

References
  1. "List of International Non-Proprietary Names (INNs), Provided for Pharmaceutical Substances by the World Health Organization, Which Are Free of Duty". Official Journal of the European Communities. 23 October 2001. Archived from the original (PDF) on 27 June 2014. Retrieved 7 December 2009.
  2. Hrib NJ, Martin LL (1989). Chapter 2. Antianxiety Agents and Anticonvulsants. Annual Reports in Medicinal Chemistry. Vol. 24. pp. 11–20. doi:10.1016/s0065-7743(08)60524-2. ISBN 9780120405244.
  3. Pérez C, Mondelo N, Stéfano FJ, Lores Arnaiz J (May 1988). "Pharmacological activity of novel alkylsulfonylaryl-1-substituted-1,4-benzodiazepine derivatives". Archives Internationales de Pharmacodynamie et de Therapie. 293: 57–68. PMID 2901826.
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