RU-24,969

RU-24,969 is a chemical compound widely used in scientific studies. It is a selective agonist at the 5-HT1A and 5-HT1B receptors, with preference for the latter.[1] As with other 5-HT1B agonists such as CP-94,253, RU-24,969 has been found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.[2]

RU-24,969
Identifiers
  • 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H16N2O
Molar mass228.295 g·mol−1
3D model (JSmol)
  • c3cc(OC)cc1c3[nH]cc1C=2CCNCC=2
  • InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3 ☒N
  • Key:KRVMLPUDAOWOGN-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

See also

References
  1. Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA (1985). "Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity". Eur J Pharmacol. 112 (3): 363–370. doi:10.1016/0014-2999(85)90782-4. PMID 3160596.
  2. Parsons LH, Weiss F, Koob GF (December 1998). "Serotonin1B receptor stimulation enhances cocaine reinforcement". Journal of Neuroscience. 18 (23): 10078–89. doi:10.1523/JNEUROSCI.18-23-10078.1998. PMC 6793270. PMID 9822762.


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