Pholedrine

Pholedrine (Paredrinol, Pulsotyl, Veritol), also known as 4-hydroxy-N-methylamphetamine (4-HMA), 4-hydroxymethamphetamine, and para-hydroxymethamphetamine,[1] is a drug that stimulates the sympathetic nervous system.[2] It is administered as a topical eye drop form for the purpose of dilating the pupil and can be used to diagnose Horner's syndrome.[2]

Pholedrine
Clinical data
Routes of
administration		Topical (Ocular)
Identifiers
  • 4-[2-(Methylamino)propyl]phenol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.006.114
Chemical and physical data
FormulaC10H15NO
Molar mass165.236 g·mol−1
3D model (JSmol)
  • Oc1ccc(cc1)CC(NC)C
  • InChI=1S/C10H15NO/c1-8(11-2)7-9-3-5-10(12)6-4-9/h3-6,8,11-12H,7H2,1-2H3 ☒N
  • Key:SBUQZKJEOOQSBV-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

4-hydroxymethamphetamine is also a major metabolite of methamphetamine.

See also

References
  1. "Pholedrine". National Library of Medicine. Retrieved 24 June 2023.
  2. Bates AT, Chamberlain S, Champion M, Foley L, Hughes E, Jani B, et al. (February 1995). "Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome". Journal of Neurology, Neurosurgery, and Psychiatry. 58 (2): 215–7. doi:10.1136/jnnp.58.2.215. PMC 1073320. PMID 7876854.
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