LTBP1 (gene)

LTBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KSQ
Identifiers
Aliases	LTBP1, latent transforming growth factor beta binding protein 1
External IDs	OMIM: 150390 MGI: 109151 HomoloGene: 522 GeneCards: LTBP1
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	33,399,509 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	75,699,507 bp[2]
RNA expression pattern
	Top expressed in
	right coronary artery; ; ascending aorta; ; saphenous vein; ; stromal cell of endometrium; ; urethra; ; popliteal artery; ; left coronary artery; ; periodontal fiber; ; tibia; ; Achilles tendon;
	Top expressed in
	ascending aorta; ; cumulus cell; ; aortic valve; ; ciliary body; ; belly cord; ; atrium; ; blood; ; endocardial cushion; ; cervix; ; coelomic epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; calcium ion binding; transforming growth factor beta-activated receptor activity; growth factor binding; microfibril binding; transforming growth factor beta binding; extracellular matrix structural constituent;
Cellular component	extracellular matrix; microfibril; extracellular space; endoplasmic reticulum lumen; extracellular region; protein-containing complex; collagen-containing extracellular matrix;
Biological process	ventricular septum development; sequestering of TGFbeta in extracellular matrix; coronary vasculature development; aorta development; transmembrane receptor protein serine/threonine kinase signaling pathway; post-translational protein modification; regulation of transforming growth factor beta activation;
	Sources:Amigo / QuickGO
Orthologs
	4052
	268977
	ENSG00000049323
	ENSMUSG00000001870
	Q14766
	Q8CG19
	NM_000627; NM_001166264; NM_001166265; NM_001166266; NM_206943
NM_019919; NM_206958; NM_001331233; NM_001331234; NM_001331235;
	NM_001331236; NM_001331237
	NP_000618; NP_001159736; NP_001159737; NP_001159738; NP_996826
NP_001318162; NP_001318163; NP_001318164; NP_001318165; NP_001318166;
	NP_064303; NP_996841
	Wikidata
View/Edit Human	View/Edit Mouse

Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.[5][6][7]

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

Interactions

LTBP1 (gene) has been shown to interact with TGF beta 1.[8]

References

GRCh38: Ensembl release 89: ENSG00000049323 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000001870 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH (July 1990). "TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences". Cell. 61 (6): 1051–1061. doi:10.1016/0092-8674(90)90069-Q. PMID 2350783. S2CID 54376541.
Oklu R, Hesketh R (January 2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem J. 352 (3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.
"Entrez Gene: LTBP1 latent transforming growth factor beta binding protein 1".
Saharinen, J; Keski-Oja J (August 2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. ISSN 1059-1524. PMC 14949. PMID 10930463.

Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action". Cytokine Growth Factor Rev. 10 (2): 99–117. doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
Keski-Oja J, Koli K, von Melchner H (2005). "TGF-beta activation by traction?". Trends Cell Biol. 14 (12): 657–659. doi:10.1016/j.tcb.2004.10.003. PMID 15564041.
Stenman G, Sahlin P, Olofsson A, et al. (1994). "Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12→q22". Cytogenet. Cell Genet. 66 (2): 117–119. doi:10.1159/000133680. PMID 8287682.
Olofsson A, Ichijo H, Morén A, et al. (1996). "Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix". J. Biol. Chem. 270 (52): 31294–31297. doi:10.1074/jbc.270.52.31294. PMID 8537398.
Saharinen J, Taipale J, Keski-Oja J (1996). "Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1". EMBO J. 15 (2): 245–53. doi:10.1002/j.1460-2075.1996.tb00355.x. PMC 449939. PMID 8617200.
Taipale J, Saharinen J, Hedman K, Keski-Oja J (1996). "Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils". J. Histochem. Cytochem. 44 (8): 875–89. doi:10.1177/44.8.8756760. PMID 8756760.
Nunes I, Gleizes PE, Metz CN, Rifkin DB (1997). "Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta". J. Cell Biol. 136 (5): 1151–1163. doi:10.1083/jcb.136.5.1151. PMC 2132473. PMID 9060478.
Karonen T, Jeskanen L, Keski-Oja J (1997). "Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma". Br. J. Dermatol. 137 (1): 51–58. doi:10.1111/j.1365-2133.1997.tb03700.x. PMID 9274625.
Dallas SL, Keene DR, Bruder SP, et al. (2000). "Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo". J. Bone Miner. Res. 15 (1): 68–81. doi:10.1359/jbmr.2000.15.1.68. PMID 10646116. S2CID 10766165.
Saharinen J, Keski-Oja J (2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. PMC 14949. PMID 10930463.
Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3". Biochem. J. 369 (Pt 2): 311–8. doi:10.1042/BJ20020809. PMC 1223078. PMID 12358597.
Isogai Z, Ono RN, Ushiro S, et al. (2003). "Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein". J. Biol. Chem. 278 (4): 2750–2757. doi:10.1074/jbc.M209256200. PMID 12429738.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gui Y, Murphy LJ (2004). "Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1". Mol. Cell. Biochem. 250 (1–2): 189–195. doi:10.1023/A:1024990409102. PMID 12962157. S2CID 6372795.
Weikkolainen K, Keski-Oja J, Koli K (2004). "Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblasts". Growth Factors. 21 (2): 51–60. doi:10.1080/08977198310001598778. PMID 14626352. S2CID 42812652.
Shariat SF, Kattan MW, Traxel E, et al. (2004). "Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression". Clin. Cancer Res. 10 (6): 1992–1999. doi:10.1158/1078-0432.CCR-0768-03. PMID 15041717.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000049323 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001870 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2350783-5] Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH (July 1990). "TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences". Cell. 61 (6): 1051–1061. doi:10.1016/0092-8674(90)90069-Q. PMID 2350783. S2CID 54376541.

[pmid11104663-6] Oklu R, Hesketh R (January 2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem J. 352 (3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.

[entrez-7] "Entrez Gene: LTBP1 latent transforming growth factor beta binding protein 1".

[pmid10930463-8] Saharinen, J; Keski-Oja J (August 2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. ISSN 1059-1524. PMC 14949. PMID 10930463.

LTBP1 (gene)

Interactions

References

Further reading