LEFTY2

LEFTY2
Identifiers
Aliases	LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2
External IDs	OMIM: 601877 MGI: 2443573 HomoloGene: 2434 GeneCards: LEFTY2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	225,941,383 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	180,726,668 bp[2]
RNA expression pattern
	Top expressed in
	myometrium; ; sperm; ; canal of the cervix; ; ascending aorta; ; right coronary artery; ; popliteal artery; ; caput epididymis; ; smooth muscle tissue; ; left coronary artery; ; anterior pituitary;
	Top expressed in
	mesoderm; ; neural plate; ; primitive streak; ; inner cell mass; ; blastocyst; ; hippocampal formation; ; hippocampus proper; ; floor plate; ; ascending aorta; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transforming growth factor beta receptor binding; cytokine activity; growth factor activity;
Cellular component	extracellular matrix; extracellular region; platelet alpha granule lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	multicellular organism development; regulation of apoptotic process; positive regulation of pathway-restricted SMAD protein phosphorylation; cell growth; platelet degranulation; regulation of MAPK cascade; transforming growth factor beta receptor signaling pathway; SMAD protein signal transduction; cell development; BMP signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	7044
	320202
	ENSG00000143768
	ENSMUSG00000066652
	O00292
	P57785
	NM_001172425; NM_003240
	NM_177099
	NP_001165896; NP_003231
	NP_796073
	Wikidata
View/Edit Human	View/Edit Mouse

Left-right determination factor 2 is a protein that in humans is encoded by the LEFTY2 gene. [5]

Function

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

References

GRCh38: Ensembl release 89: ENSG00000143768 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000066652 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Left-right determination factor 2". Retrieved 2016-04-19.

LEFTY2

Function

References

Further reading