Ergocristine

Ergocristine is an ergopeptine and one of the ergot alkaloids.[1] As of February 24, 2010 ergocristine has been federally regulated. Because of the existing Controlled Substance Act regulatory controls on the LSD precursors lysergic acid, lysergic acid amide, ergotamine, and ergonovine, clandestine laboratory operators have sought uncontrolled sources of precursor material for the production of LSD. This has led to the illicit utilization of the precursor chemical ergocristine as a direct substitute for ergotamine and ergonovine for the illicit production of LSD. In fact, the largest clandestine LSD laboratory ever, William Leonard Pickard and Clyde Apperson, that was seized by the Drug Enforcement Administration (DEA) utilized ergocristine as the LSD precursor according to court documents.[2]

Not to be confused with Ergocryptine.
Ergocristine
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.007.383
Chemical and physical data
FormulaC35H39N5O5
Molar mass609.727 g·mol−1
3D model (JSmol)
  • O=C3N1CCC[C@H]1[C@]2(O)O[C@](C(=O)N2[C@H]3Cc4ccccc4)(NC(=O)[C@@H]8/C=C7/c5cccc6c5c(c[nH]6)C[C@H]7N(C)C8)C(C)C
  • InChI=1S/C35H39N5O5/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34/h4-7,9-12,16,18,20,23,27-29,36,44H,8,13-15,17,19H2,1-3H3,(H,37,41)/t23-,27-,28+,29+,34-,35+/m1/s1 ☒N
  • Key:HEFIYUQVAZFDEE-MKTPKCENSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

The DEA determined that ergocristine was readily available from commercial chemical suppliers. DEA had identified at least three suppliers of ergocristine, of which one distributor is located domestically; the other two are based in Germany and the Czech Republic.[3][2]

References
  1. Stoll A (1952). "Recent investigations on ergot alkaloids". Fortschritte der Chemie Organischer Naturstoffe: 114–174 (159).
  2. "Control of Ergocristine, a Chemical Precursor Used in the Illicit Manufacture of Lysergic Acid Diethylamide, as a List I Chemical" (PDF). Microgram Bulletin. 43 (3): 24. 2010.
  3. "DEA Diversion Control Division".


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