Xiaodong Wang (biochemist)

Xiaodong Wang (simplified Chinese: 王晓东; traditional Chinese: 王曉東; pinyin: Wāng Xiǎodōng, born 1963) is a Chinese biochemist best known for his work with cytochrome c.[1] His laboratory developed an in vitro assay for the activation of the apoptosis related proteinase Caspase-3. This allowed the biochemical purification of a complex of Cytochrome c, Caspase-9 and the Apoptotic Protease Activating factor-1 (APAF1). These components are essential for forming a ternary complex called the apoptosome that activates Caspase-3 downstream of the intracellular or mitochondrial pathway of apoptosis.[2]

For the engineer, see Xiaodong Wang (electrical engineer).
The native form of this personal name is Wang Xiaodong. This article uses Western name order when mentioning individuals.
Wang Xiaodong
simplified Chinese: 王晓东; traditional Chinese: 王曉東; pinyin: Wāng Xiǎodōng
Born1963
Xinxiang, Henan, China
CitizenshipChina
EducationBeijing Normal University, Southwestern Medical College of the University of Texas (PhD 1991)
Known forWork with cytochrome c
AwardsAcademia Sinica, National Academy of Sciences, Shaw Prize in Life Science and Medicine, Richard Lounsbery Award, from the National Academy of Sciences, King Faisal International Prize in Medicine
Scientific career
FieldsBiochemistry
InstitutionsNational Institute of Biological Sciences, Peking

He was awarded the 2006 Shaw Prize in Life Science and Medicine.[3]

Wang is a member of United States National Academy of Sciences and the Howard Hughes Medical Institute. Currently he is the director of the National Institute of Biological Sciences, Beijing.[4]

Honors and awards

References
  1. Zagorski, N. (2006). "Profile of Xiaodong Wang (biochemist)". Proceedings of the National Academy of Sciences. 103 (1): 7–9. doi:10.1073/pnas.0509187103. PMC 1324996. PMID 16380419.
  2. Zou, H.; Henzel, W. J.; Liu, X.; Lutschg, A.; Wang, X. (1997-08-08). "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3". Cell. 90 (3): 405–413. doi:10.1016/s0092-8674(00)80501-2. ISSN 0092-8674. PMID 9267021. S2CID 18105320.
  3. "Announcement and Citation - Life Science and Medicine - 2006". The Shaw Prize. 2006-06-21. Retrieved 2016-04-16.
  4. "Xiaodong Wang". National Institute of Biological Sciences, Beijing. Retrieved 2016-04-15.
  5. International King Faisal Prize 2020
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