U.S. Route 27 in Ohio

US 27 enters Ohio on the Taylor–Southgate Bridge over the Ohio River as a four-lane highway. After the bridge ends, the highway makes a loop to the east around a parking structure on Pete Rose Way and Mehring Way, concurrent with US 52. Mehring Way curves towards the west and passes under the Taylor–Southgate Bridge. After the bridge the street parallels the Ohio River and Cincinnati Riverfront Park on the south side of the road, and the U.S. Bank Arena and the Great American Ballpark on the north side. The street passes under the Roebling Bridge, and then passes to the south of Paycor Stadium.

On the southwest corner of the stadium US 27 and US 52 turn north onto Central Avenue. Central Avenue passes on the west side of the stadium. The route continues north passing the west side of the Duke Energy Convention Center, Cathedral Basilica of St. Peter in Chains, and the Romanesque Cincinnati City Hall. US 27 then turns east on Ezzard Charles Drive for a block before turning north on Central Parkway, becoming concurrent with US 127. US 27 leaves Central Parkway at the Hopple Street interchange and then becomes concurrent with Interstate 75 and then Interstate 74 for a short while.

The route then follows Colerain Avenue, ascending through Mount Airy Forest from elevation 490 feet to 930 ft in 2 miles, passing the Cincinnati Water Tanks on North Bend Road. The remaining stretch in Hamilton County is a quite busy multilane highway that passes through the Mount Airy neighborhood, then exits Cincinnati to briefly pass through the corner of Green Township. It then becomes the main commercial thoroughfare through Colerain Township, traveling along a broad ridge that roughly separates the watersheds of the Great Miami River to the west from that of West Fork Mill Creek to the east.

The road then splits at an intersection with Strubble Road, with the old alignment of Colerain Avenue branching off, and US 27 following a modern freeway section, passing the "Mount Rumpke" landfill, and descending to and crossing the Great Miami River at elevation 525 feet.

A herringbone brick intersection of Chestnut Street and Patterson Avenue is at the southeast corner of Oxford at U.S. 27. The highway northwest of Oxford is straight and rural being improved 10–15 years ago. This final section passes to the west of the Oxford Walmart and within a mile of the Butler co. highpoint before reaching College Corner. [2]