POLD3

POLD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1U76, 3E0J, 2N1G
Identifiers
Aliases	POLD3, P66, P68, PPP1R128, polymerase (DNA) delta 3, accessory subunit, DNA polymerase delta 3, accessory subunit
External IDs	OMIM: 611415 MGI: 1915217 HomoloGene: 38202 GeneCards: POLD3
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	74,669,117 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	99,770,772 bp[2]
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; ganglionic eminence; ; rectum; ; monocyte; ; kidney tubule; ; bronchial epithelial cell; ; right uterine tube; ; testicle; ; body of pancreas;
	Top expressed in
	secondary oocyte; ; spermatid; ; morula; ; somite; ; primitive streak; ; seminiferous tubule; ; spermatocyte; ; otic placode; ; blastocyst; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; DNA-directed DNA polymerase activity;
Cellular component	delta DNA polymerase complex; nucleus; nucleoplasm; cytoplasm;
Biological process	nucleotide-excision repair, DNA gap filling; DNA synthesis involved in DNA repair; DNA replication; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; telomere maintenance; DNA-dependent DNA replication; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA repair; cellular response to DNA damage stimulus; telomere maintenance via semi-conservative replication; DNA mismatch repair; DNA strand elongation involved in DNA replication; DNA synthesis involved in UV-damage excision repair;
	Sources:Amigo / QuickGO
Orthologs
	10714
	67967
	ENSG00000077514
	ENSMUSG00000030726
	Q15054
	Q9EQ28
	NM_006591; NM_001363597
	NM_133692; NM_001368380
	NP_006582; NP_001350526
	NP_598453; NP_001355309
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene.[5][6] It is a component of the DNA polymerase delta complex.

Interactions

POLD3 has been shown to interact with PCNA.[7][8]

References

GRCh38: Ensembl release 89: ENSG00000077514 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030726 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res. 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083.
"Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit".
Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. 276 (52): 49258–66. doi:10.1074/jbc.M106990200. PMID 11595739.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.

Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MY (1994). "DNA polymerase delta is involved in the cellular response to UV damage in human cells". J. Biol. Chem. 269 (19): 13748–51. doi:10.1016/S0021-9258(17)36709-1. PMID 7910606.
Longley MJ, Pierce AJ, Modrich P (1997). "DNA polymerase delta is required for human mismatch repair in vitro". J. Biol. Chem. 272 (16): 10917–21. doi:10.1074/jbc.272.16.10917. PMID 9099749.
Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry. 39 (24): 7245–54. doi:10.1021/bi0000871. PMID 10852724.
Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2002). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. 276 (52): 49258–66. doi:10.1074/jbc.M106990200. PMID 11595739.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Pohler JR, Otterlei M, Warbrick E (2006). "An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit". BMC Mol. Biol. 6: 17. doi:10.1186/1471-2199-6-17. PMC 1187890. PMID 16000169.
Takemura M, Yoshida S, Akiyama T, Kitagawa M, Yamada Y (2006). "Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase". Biochim. Biophys. Acta. 1764 (9): 1447–53. doi:10.1016/j.bbapap.2006.06.015. PMID 16935576.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K (2007). "Dynamics of human replication factors in the elongation phase of DNA replication". Nucleic Acids Res. 35 (20): 6904–16. doi:10.1093/nar/gkm822. PMC 2175312. PMID 17932049.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077514 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030726 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10219083-5] Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res. 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083.

[entrez-6] "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit".

[pmid11595739-7] Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. 276 (52): 49258–66. doi:10.1074/jbc.M106990200. PMID 11595739.

[pmid12171929-8] Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.

POLD3

Interactions

References

Further reading