AquAdvantage salmon

Fish are one of the eight food types that the Food and Drug Administration (FDA) is required, by law, to treat with special care, with regard to allergies.[6]^: 97 As part of the regulatory process, the FDA required data on whether changes occur in the kinds or levels of fish allergens (such as parvalbumin) in AquAdvantage. The FDA has upheld that people with allergies to Atlantic Salmon will likely be allergic to AquAdvantage Salmon due to the similar species properties, but not because it is genetically engineered[9] and that AquAdvantage Salmon is as safe to eat as non-GE salmon because there are no significant food safety hazards associated with AquAdvantage.[10] Other human health concerns arise due to the increased hormone content in the edible tissue of transgenic fish.[11] The AquAdvantage salmon showed a statistical difference in the concentration of an insulin-like growth factor, yet the amount of (IGF-1) found in AquAdvantage salmon is similar to, or lower than, other amounts found in other common animal products such as organic cow milk.[8]

A concern with genetic engineering is that another gene other than the one intended may also be accidentally edited. [5] The genome sequence of the AquAdvantage salmon has been analyzed and no off-target effects or changes in other genes have been detected. [8]

Critics raised concerns about potential environmental impacts if these fish reached the rivers or oceans. Modeled invasion scenarios in semi-natural environments suggest that GM salmon would out-compete wild-type salmon.[12][13] To address concerns about biological containment, the FDA requires AquaBounty to take precautionary measures to ensure that transgenic fish do not mix with the wild population. Aquaculture that uses conventionally bred salmon, mostly Atlantic salmon, cultivates the fish in net pens. In North America, this occurs mostly in coastal waters off Washington, British Columbia, and Maine. However, the application for FDA approval of AquAdvantage salmon specified land-based tank cultivation with no ocean involvement.[11] AquaBounty also altered the fish to be only female and sterile. Male fish are created only for egg-producing service and are kept in secure, land-based facilities in Canada. These eggs are then shipped to a land-based aquaculture facility in Indiana.

In order to make the fish sterile AquAdvantage salmon eggs are treated with pressure, to create batches of fish eggs with three copies of each chromosome (triploid) rather than to two copies (diploid). Any batch that contains 5 percent or more diploid fish, is destroyed because these diploid fish are capable of reproducing.[8]

In September 2010, an FDA advisory panel indicated that the fish is "highly unlikely to cause any significant effects on the environment" and that it is "as safe as food from conventional Atlantic salmon"[6][14] In October 2010, 39 lawmakers asked the FDA to reject the application. Other groups requested that the fish carry a label identifying its transgenic origin.[14] Concerns included alleged flaws in sterilization and isolation, and excessive antibiotic use.[15]

On 25 December 2012, the FDA published a draft environmental assessment for AquAdvantage salmon.[7] The FDA also published a preliminary Finding of No Significant Impact.[16] A 60-day period for the public to comment was to elapse before the FDA reviewed Aquadvantage salmon again, which was arbitrarily extended until May 2013.[17][18]

The Food and Drug Administration (FDA) approved AquaBounty Technologies' application to sell the AquAdvantage salmon to U.S. consumers on November 19, 2015.[19] However, a rider to a spending bill signed into law on December 18, 2015 by President Obama bans its import until the FDA mandates labels for the genetically modified product.[20][21] The decision marks the first time a genetically modified animal has been approved to enter the United States food supply. The decision came nearly twenty years after the company first submitted data to the FDA, and after they had raised ten generations of the animals.[15] The announcement released by the FDA states: "AquAdvantage salmon is as safe to eat as any non-genetically engineered (GE) Atlantic salmon, and also as nutritious."[22][23] One month later, language was introduced into a proposed federal spending bill requiring consumer notification that the fish is genetically modified.[24] In October, 2018, AquaAdvantage salmon was not being sold in the US and the import of the salmon eggs from Canada to be raised at an AquaAdvantage fish farm in Indiana was prohibited by FDA.[25] However, on March 8, 2019, the import alert issued previously by the FDA was deactivated, and AquAdvantage salmon may now be sold in the U.S. and the salmon eggs may now be imported to the Indiana facility.[26]

On November 5 2020 the United States District Court for the Northern District of California granted a motion to force the FDA to reconsider its approval of AquAdvantage, holding that the FDA had failed to follow its own procedures by ignoring some environmental consequences of these fish.[27]

Sales in the U.S. started in May 2021.[28]

On 25 November 2013, Environment Canada approved the product for salmon egg production for commercial purposes in Canada.[29] In May 2016, the Canadian Food Inspection Agency approved the sale of the GM fish.[30] In July 2017, AquaBounty Technologies said they had sold 4.5 tons of AquaAdvantage salmon fillets to customers in Canada.