Night at the Museum: Kahmunrah Rises Again

• Joshua Bassett as Nick Daley, the son of Larry Daley, and the newest security guard at the American Museum of Natural History. He was portrayed by Jake Cherry and Skyler Gisondo in the last three films.
• Jamie Demetriou as Dr. McPhee, the director of the Museum of Natural History and Larry's former boss. He was portrayed by Ricky Gervais in the last three films.
• Gillian Jacobs as Erica Daley, Larry's former wife and Nick's mother. She was portrayed by Kim Raver in the first film.
• Zachary Levi as Larry Daley, Nick's father, Erica's former husband, and the previous security guard of the museum who gets a job at the National History Museum of Japan. He was portrayed by Ben Stiller in the last three films.
• Shelby Simmons as Mia, Nick's love interest.
• Tenzing Norgay Trainor as Bodhi, a student at Nick's school.
• Lidia Porto as Ms. Montefusco, Nick’s music teacher
• Bowen Yang as Ronnie, a night guard at the museum who quits after only a few minutes because of the exhibits.

• Thomas Lennon as Theodore Roosevelt, the wax sculpture of the 26th President of the United States. He was portrayed by Robin Williams in the previous three films. Lennon portrayed Orville Wright in the second film.
• Zachary Levi as Laaa, a Neanderthal who was made to resemble Larry. He was portrayed by Ben Stiller in the last film.
• Alice Isaaz as Joan of Arc, the statue of the woman, who led the French in war against the English, and sees visions of the future.
• Jack Whitehall as Octavius, a Roman soldier diorama miniature and Jedediah's best friend. He was portrayed by Steve Coogan in the last three films.
• Steve Zahn as Jedediah, a cowboy diorama miniature and Octavius' best friend. He was portrayed by Owen Wilson in the last three films.
• Joseph Kamal as Kahmunrah, a pharaoh who is Ahkmenrah's older brother and seeks revenge from Larry. He was portrayed by Hank Azaria in the second film.
• Alexander Salamat as Attila the Hun, the statue of the leader of the Huns. He was portrayed by Patrick Gallagher in the last three films.
• Kieran Sequoia as Sacagawea, the polyurethane model of the Lemhi Shoshone woman who is Theodore Roosevelt's girlfriend. She was portrayed by Mizuo Peck in the last three films.
• Akmal Saleh as Seth, the Egyptian God of Chaos who helps Kahmunrah with his quest, to conquer the world.
• Chris Parnell as George Washington, the 1st President of the United States. He appears in the famous painting "Washington Crossing the Delaware".
• Dee Bradley Baker as Dexter, a Capuchin monkey. He was portrayed by Crystal the Monkey in the last three films.
• Kelemete Misipeka as Moai, an Easter Island Head at the Museum of Natural History. He was voiced by Brad Garrett in the last three films.
• Jonathan Roumie as Merenkahre, the mummy of an ancient pharaoh and Kahmunrah's father who appears on different carvings seen throughout the film. He was portrayed by Ben Kingsley in the last film.
• Zeeko Zaki as Ra, the Egyptian Sun God whose head appears on the temple in an Ancient Egypt painting.

In 2016, it was reported that a remake of Night at the Museum was in development from Alibaba Pictures Group.[2] By August 2018, then-CEO of 20th Century Fox Stacey Snider announced that a television series based on Night at the Museum was in development instead.[3] In August 2019, after the acquisition of 21st Century Fox by Disney, the project was confirmed to be still in development as a Disney+ exclusive film.[4][5]

In October 2020, it was reported that an animated film titled Night at the Museum: Kahmunrah Rises Again was in development. The plot centers around Larry's son, Nick, who is hesitant to follow in his father's footsteps as nightwatchman. In addition to Nick and Kahmunrah, the film also features other returning characters: Jedediah, Octavius, Theodore "Teddy" Roosevelt and Sacagawea, with the addition of Joan of Arc. In August 2021, Shawn Levy said that the film would debut on Disney+ in 2022.[6] In September 2022, Matt Danner revealed he was directing the film; he previously was the creator and showrunner of the Disney animated show Legend of the Three Caballeros (2018).[7] Several crew members from Legend of the Three Caballeros worked on the film, with Danner describing it as a "spiritual successor" to the series.[8][9] In November 2022, the release date of December 9, 2022 was revealed.[1]

The animation was handled by Atomic Cartoons, using the same style they used from their previous work, Little Demon, enhancing lighting and character rigging. The film has a 2D animation style, making it the first 2D animated film released under Walt Disney Pictures since Winnie the Pooh.[10]

In March 2022, John Paesano revealed that he was composing the film.[11] By August 29, 2022, Paesano was confirmed as composer, replacing Alan Silvestri from the first three films.[12]