New Tales from the Borderlands

Set about a year after Borderlands 3, weapon manufacturer Tediore has begun invading the planet Promethea. New Tales from the Borderlands introduces a cast of new characters, including three playable protagonists: Anuradha Dhar (Michelle Rambharose), an altruistic scientist; Octavio Wallace-Dhar (Diego Stredel), Anu's brother who is seeking for fame and fortune; and Francine Miscowicz (Lucia Frangione), the owner of a frozen yogurt store who uses a hoverchair for mobility.[3] The player must guide the three protagonists, each with their own hopes and dreams, as they fight against Tediore agents, as well as monsters and criminals that roam the planet. The trio must also work together as they seek a Vault key which may grant them access to a vault stashed with treasures that may change their lives forever.[4][5] Major non-playable characters include: L0U13 (Temapare Hodson), an assassination bot allied with the three protagonists; Rhys Strongfork (Ray Chase), CEO of Atlas and previously one of the two playable protagonists of Tales from the Borderlands; and Susan Coldwell (Samantha Ferris), CEO of Tediore and the major antagonist of the game. Weapon salesman Marcus Kincaid (Bruce DuBose) returns as the narrator of the game, while Fiona (Laura Bailey), the other playable protagonist of Tales, makes a cameo appearance in the ending.

Atlas scientist Anuradha Dhar attempts to present her invention, a non-lethal ray gun utilizing Eridium to mimic Siren powers, to her boss, Rhys Strongfork, but the device is rejected and she is fired from her job. Just as she returns to her office, the Atlas space station is under siege by Tediore forces, who are attempting to acquire a Vault Key from Rhys. Anu escapes to Promethea using Rhys' car. Meanwhile, on Promethea, Anu's estranged half-brother, Octavio Wallace-Dhar, also struggles to survive the Tediore invasion alongside his friend, assassination bot L0U13. Anu and Octavio later reunite at Fran's Frogurt, a failing frozen yogurt shop owned by Octavio's boss, Francine Miscowicz. After Tediore forces decimate the shop while looking for Octavio, the three of them agree to ally and find out Tediore's plan.

Anu, Octavio, and Fran follow Tediore troops to the sewers, where they discover a Vault entrance. Upon entering, they are forced to face the Vault's guardian, the Devourer. With their combined efforts, they defeat the Devourer and retrieve a green shard from its body, which they later learn has healing capabilities. On Octavio's suggestion, the trio signs up for the reality game show Sink or Swim to pitch the shard, combined with Anu's ray gun, as an invention, in order to win the prize money and start their own business. Though Anu nearly loses her life while making her sales pitch, they manage to win the competition with backing from an angel investor. Anu later learns, however, that Tediore had put a bounty on her head, having recovered her ID card from the Vault. Tediore forces later attack the shop and kill Anu, though Octavio is able to revive her using her ray gun. However, Anu is temporarily possessed by an unknown entity, who demands that they are reunited with their "twin".

Octavio contacts the angel investor to seek refuge, to which they agree. However, it turns out to be a trap as Tediore's CEO, Susan Coldwell, reveals herself as the angel investor in disguise. After capturing the trio and L0U13, Coldwell makes a presentation to other mega-corporation CEOs, revealing that the green shard is one-half of a full Anahatium shard, and that she was in possession of the other half; with both shards, Coldwell can power up a superweapon capable of torturing others by killing and resurrecting them repeatedly. As she demands the other corporations to merge with Tediore by choice or force, the entity within Anu becomes enraged and breaks free from containment, while also fusing the green shard with Anu's body. Coldwell detains them once more, and instructs her scientists to remove the shard from Anu.

Octavio, Fran and L0U13 manage to break free on their own and reunite with each other, then later find Anu, who had a conversation with the shard's spirit entity while in coma. They learn that Coldwell had constructed a gigantic-sized version of Anu's device. After L0U13 sacrifices himself, the trio moves on and confronts Coldwell, who uses her super gun on the entirety of Promethea. Anu is faced with a choice: to merge with the shard and become a corporeal entity, killing her mortal form and gaining the power to defeat Coldwell, or resist the shard and work with Octavio and Fran. Regardless of the choices, Coldwell is killed and the Anahatium shard is fully reunited, as it flies away into space, and Promethea's population is restored.

Depending on the player's choices, there are several possible endings, which are reliant on the bond between the playable characters. There are three endings, each of which feature one of the characters dying; another ending where they survive but go their separate ways; or an ending where they survive and start a new business together, alongside all of their friends on Promethea as well as a rebuilt L0U13. Meanwhile, it is revealed that Marcus Kincaid is narrating the story to Fiona, a con artist and Vault Hunter, who deduces where the Anahatium shard ends up next.