N-myc internal ribosome entry site (IRES)
The N-myc internal ribosome entry site (IRES) is an RNA element found in the n-myc gene. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis. n-myc mRNA has an alternative method of translation via an internal ribosome entry site where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.[1]
| n-myc internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_n-myc | |
| Identifiers | |
| Symbol | IRES_n-myc |
| Alt. Symbols | n-myc_IRES |
| Rfam | RF00226 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
See also
References
- Jopling CL, Willis AE (May 2001). "N-myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells". Oncogene. 20 (21): 2664–2670. doi:10.1038/sj.onc.1204404. PMID 11420678.
External links
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