Michael Sternberg

Michael Joseph Ezra Sternberg (born 24 June 1951)[1] is a professor at Imperial College London, where he is director of the Centre for Integrative Systems Biology and Bioinformatics[4] and Head of the Structural bioinformatics Group.[2][5][6][7]

For the Grand Master of the Teutonic Knights, see Michael Küchmeister von Sternberg.

Mike Sternberg
Born
Michael Joseph Ezra Sternberg

(1951-06-24) 24 June 1951[1]
Alma mater
Awards
Scientific career
Fields
Institutions
ThesisStudies of Protein Conformation (1977)
Doctoral advisorDavid Chilton Phillips[3]
Websitewww.imperial.ac.uk/people/m.sternberg

Education

Sternberg was educated at Hendon County Grammar School and Gonville and Caius College, Cambridge, where he was awarded a Bachelor of Arts degree in natural sciences (theoretical physics) in 1972.[1] He went on to do a Master of Science degree in Computing at Imperial College London followed by a DPhil degree from the University of Oxford (Wolfson College, Oxford) in 1978 for research supervised by David Chilton Phillips.[3][8][9][10][11][12]

Career

After postdoctoral research at the University of Oxford, Sternberg became a Lecturer in the Department of Crystallography at Birkbeck College, London. He went on to work at the Imperial Cancer Research Fund and joined Imperial College in 2001.[1][13][14][15][16] He is the Director of the Centre for Integrative Systems Biology and Bioinformatics[4] at Imperial College.

Research

Sternberg's research interests are in protein structure prediction, protein function prediction, prediction of macromolecular docking and interactions, network modelling for systems biology and logic-based drug design.[13][17][18][19][20][21][22][23][24][25]

He has authored or co-authored several books including From Cells to Atoms: an illustrated introduction to molecular biology,[26] Protein Engineering: a practical approach[27] and Protein Structure Prediction: a practical approach.[28]

During his DPhil research at Oxford he worked with Janet Thornton and they undertook some of the first systematic analyses of protein structure. They identified that the beta-alpha-beta unit in proteins is nearly always right handed and this explained remarkable similarities between protein structures.

His group, particularly Lawrence Kelley, have developed the widely used Phyre/Phyre2 web server[29][30][31] for protein structure prediction. This web resource has been used by over 100,000 distinct users worldwide.

Recently his PhD student Chris Yates developed SuSPect,[32] a novel powerful method to predict the phenotypic effects of Single-nucleotide polymorphisms and other amino acid variants.

Awards and honours

Sternberg was elected a Fellow of the Royal Society of Biology (FRSB) and a Fellow of the Institute of Biology (FIBiol). He is an associate editor of the Journal of Molecular Biology.

References
  1. "STERNBERG, Prof. Michael Joseph Ezra". Who's Who. Vol. 2014 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  2. Michael Sternberg publications indexed by Google Scholar
  3. Sternberg, Michael Joseph Ezra (1977). Studies of protein conformation (DPhil thesis). University of Oxford.
  4. "Imperial College London".
  5. Michael Sternberg's publications indexed by the Scopus bibliographic database. (subscription required)
  6. Michael J. E. Sternberg at DBLP Bibliography Server
  7. Michael Sternberg publications indexed by Microsoft Academic
  8. Cohen, F. E.; Sternberg, M. J.; Phillips, D. C.; Kuntz, I. D.; Kollman, P. A. (1980). "A diffusion--collision--adhesion model for the kinetics of myoglobin refolding". Nature. 286 (5773): 632–4. Bibcode:1980Natur.286..632C. doi:10.1038/286632a0. PMID 7402344. S2CID 4348559.
  9. Artymiuk, P. J.; Blake, C. C.; Grace, D. E.; Oatley, S. J.; Phillips, D. C.; Sternberg, M. J. (1979). "Crystallographic studies of the dynamic properties of lysozyme". Nature. 280 (5723): 563–8. Bibcode:1979Natur.280..563A. doi:10.1038/280563a0. PMID 460438. S2CID 32299121.
  10. Sternberg, M. J.; Grace, D. E.; Phillips, D. C. (1979). "Dynamic information from protein crystallography. An analysis of temperature factors from refinement of the hen egg-white lysozyme structure". Journal of Molecular Biology. 130 (3): 231–52. doi:10.1016/0022-2836(79)90539-4. PMID 469942.
  11. Phillips, D. C.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1978). "An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenase". Journal of Molecular Biology. 119 (2): 329–51. doi:10.1016/0022-2836(78)90440-0. PMID 633372.
  12. Phillips, D. C.; Rivers, P. S.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1977). "An analysis of the three-dimensional structure of chicken triose phosphate isomerase". Biochemical Society Transactions. 5 (3): 642–7. doi:10.1042/bst0050642. PMID 902882.
  13. Michael Sternberg, Imperial College London
  14. Sternberg, M. J.; Thornton, J. M. (1978). "Prediction of protein structure from amino acid sequence". Biochemical Society Transactions. 6 (6): 1119–23. doi:10.1042/bst0061119. PMID 744369.
  15. Sternberg, M. J.; Thornton, J. M. (1978). "Prediction of protein structure from amino acid sequence". Nature. 271 (5640): 15–20. Bibcode:1978Natur.271...15S. doi:10.1038/271015a0. PMID 342964. S2CID 4160357.
  16. Blundell, T. L.; Sibanda, B. L.; Sternberg, M. J.; Thornton, J. M. (1987). "Knowledge-based prediction of protein structures and the design of novel molecules". Nature. 326 (6111): 347–52. Bibcode:1987Natur.326..347B. doi:10.1038/326347a0. PMID 3550471. S2CID 4330510.
  17. Wass, M. N.; Barton, G.; Sternberg, M. J. E. (2012). "Comb Func: Predicting protein function using heterogeneous data sources". Nucleic Acids Research. 40 (Web Server issue): W466–W470. doi:10.1093/nar/gks489. PMC 3394346. PMID 22641853.
  18. Kelley, L. A.; MacCallum, R. M.; Sternberg, M. J. E. (2000). "Enhanced genome annotation using structural profiles in the program 3D-PSSM". Journal of Molecular Biology. 299 (2): 501–522. doi:10.1006/jmbi.2000.3741. PMID 10860755.
  19. Gabb, H. A.; Jackson, R. M.; Sternberg, M. J. E. (1997). "Modelling protein docking using shape complementarity, electrostatics and biochemical information". Journal of Molecular Biology. 272 (1): 106–20. doi:10.1006/jmbi.1997.1203. PMID 9299341.
  20. Barton, G. J.; Sternberg, M. J. (1987). "A strategy for the rapid multiple alignment of protein sequences. Confidence levels from tertiary structure comparisons". Journal of Molecular Biology. 198 (2): 327–37. doi:10.1016/0022-2836(87)90316-0. PMID 3430611.
  21. Zvelebil, M. J.; Barton, G. J.; Taylor, W. R.; Sternberg, M. J. (1987). "Prediction of protein secondary structure and active sites using the alignment of homologous sequences". Journal of Molecular Biology. 195 (4): 957–61. doi:10.1016/0022-2836(87)90501-8. PMID 3656439.
  22. King, R. D.; Sternberg, M. J. E. (1996). "Identification and application of the concepts important for accurate and reliable protein secondary structure prediction". Protein Science. 5 (11): 2298–2310. doi:10.1002/pro.5560051116. PMC 2143286. PMID 8931148.
  23. Lewis, T. E.; Sillitoe, I; Andreeva, A; Blundell, T. L.; Buchan, D. W.; Chothia, C; Cozzetto, D; Dana, J. M.; Filippis, I; Gough, J; Jones, D. T.; Kelley, L. A.; Kleywegt, G. J.; Minneci, F; Mistry, J; Murzin, A. G.; Ochoa-Montaño, B; Oates, M. E.; Punta, M; Rackham, O. J.; Stahlhacke, J; Sternberg, M. J.; Velankar, S; Orengo, C (2015). "Genome3D: Exploiting structure to help users understand their sequences". Nucleic Acids Research. 43 (Database issue): D382–6. doi:10.1093/nar/gku973. PMC 4384030. PMID 25348407.
  24. Radivojac, P.; Clark, W. T.; Oron, T. R.; Schnoes, A. M.; Wittkop, T.; Sokolov, A.; Graim, K.; Funk, C.; Verspoor, K.; Ben-Hur, A.; Pandey, G.; Yunes, J. M.; Talwalkar, A. S.; Repo, S.; Souza, M. L.; Piovesan, D.; Casadio, R.; Wang, Z.; Cheng, J.; Fang, H.; Gough, J.; Koskinen, P.; Törönen, P.; Nokso-Koivisto, J.; Holm, L.; Cozzetto, D.; Buchan, D. W. A.; Bryson, K.; Jones, D. T.; et al. (2013). "A large-scale evaluation of computational protein function prediction". Nature Methods. 10 (3): 221–227. doi:10.1038/nmeth.2340. PMC 3584181. PMID 23353650.
  25. Lewis, T. E.; Sillitoe, I; Andreeva, A; Blundell, T. L.; Buchan, D. W.; Chothia, C; Cuff, A; Dana, J. M.; Filippis, I; Gough, J; Hunter, S; Jones, D. T.; Kelley, L. A.; Kleywegt, G. J.; Minneci, F; Mitchell, A; Murzin, A. G.; Ochoa-Montaño, B; Rackham, O. J.; Smith, J; Sternberg, M. J.; Velankar, S; Yeats, C; Orengo, C (2013). "Genome3D: A UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains". Nucleic Acids Research. 41 (Database issue): D499–507. doi:10.1093/nar/gks1266. PMC 3531217. PMID 23203986.
  26. From Cells to Atoms: an illustrated introduction to molecular biology ISBN 0632008881
  27. Protein Engineering: a practical approach ISBN 0199631387
  28. Protein Structure Prediction: a practical approach ISBN 0199634963|
  29. Kelley, L. A.; Sternberg, M. J. E. (2009). "Protein structure prediction on the Web: A case study using the Phyre server". Nature Protocols. 4 (3): 363–71. doi:10.1038/nprot.2009.2. hdl:10044/1/18157. PMID 19247286. S2CID 12497300.
  30. Bennett-Lovsey, R. M.; Herbert, A. D.; Sternberg, M. J. E.; Kelley, L. A. (2007). "Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre". Proteins: Structure, Function, and Bioinformatics. 70 (3): 611–625. doi:10.1002/prot.21688. PMID 17876813. S2CID 23530683.
  31. "Redirecting to Phyre2".
  32. Yates, C. M.; Filippis, I; Kelley, L. A.; Sternberg, M. J. (2014). "SuSPect: Enhanced prediction of single amino acid variant (SAV) phenotype using network features". Journal of Molecular Biology. 426 (14): 2692–701. doi:10.1016/j.jmb.2014.04.026. PMC 4087249. PMID 24810707.
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