MYO1F

MYO1F
Identifiers
Aliases	MYO1F, myosin IF
External IDs	OMIM: 601480 MGI: 107711 HomoloGene: 56276 GeneCards: MYO1F
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	8,577,577 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	33,826,738 bp[2]
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; bone marrow cells; ; right lung; ; appendix; ; upper lobe of left lung; ; sural nerve; ; cancellous bone; ; periodontal fiber;
	Top expressed in
	blood; ; spleen; ; calvaria; ; thymus; ; subcutaneous adipose tissue; ; right lung lobe; ; mammary gland; ; white adipose tissue; ; body of femur; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; actin binding; cytoskeletal motor activity; ATP binding; calmodulin binding; microtubule motor activity; microtubule binding;
Cellular component	unconventional myosin complex; myosin complex;
Biological process	biological process; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	4542
	17916
	ENSG00000142347
	ENSMUSG00000024300
	O00160
	P70248
	NM_012335; NM_001348355
	NM_053214
	NP_036467; NP_001335284
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-If is a protein that in humans is encoded by the MYO1F gene.[5][6][7]

It is expressed mainly in the immune system and might be involved in cell adhesion and motility.[8] It is a candidate gene for (among other things) nonsyndromic deafness.[9]

References

GRCh38: Ensembl release 89: ENSG00000142347 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024300 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.
Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
"Entrez Gene: MYO1F myosin IF".
Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA (October 2006). "Modulation of cell adhesion and motility in the immune system by Myo1f". Science. 314 (5796): 136–9. Bibcode:2006Sci...314..136K. doi:10.1126/science.1131920. PMID 17023661. S2CID 12479761.
Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ (August 2001). "MYO1F as a candidate gene for nonsyndromic deafness, DFNB15". Arch. Otolaryngol. Head Neck Surg. 127 (8): 921–5. doi:10.1001/archotol.127.8.921. PMID 11493199.

Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142347 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024300 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119401-5] Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.

[pmid8884266-6] Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.

[entrez-7] "Entrez Gene: MYO1F myosin IF".

[pmid17023661-8] Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA (October 2006). "Modulation of cell adhesion and motility in the immune system by Myo1f". Science. 314 (5796): 136–9. Bibcode:2006Sci...314..136K. doi:10.1126/science.1131920. PMID 17023661. S2CID 12479761.

[pmid11493199-9] Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ (August 2001). "MYO1F as a candidate gene for nonsyndromic deafness, DFNB15". Arch. Otolaryngol. Head Neck Surg. 127 (8): 921–5. doi:10.1001/archotol.127.8.921. PMID 11493199.

MYO1F

References

Further reading