MMPIP

MMPIP
Identifiers
	IUPAC name 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one;
CompTox Dashboard (EPA)	DTXSID90433202 ;
Chemical and physical data
Formula	C19H19N3O3
Molar mass	337.379 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc3ccc(cc3)C2CC(C1C(=O)N2C)ON=C1c4ccncc4;
	(verify)

MMPIP is a drug used in scientific research that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR₇.[1] This receptor subtype appears to be involved in the downstream response to cocaine in the brain.[2]

References

Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H (October 2007). "In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists". The Journal of Pharmacology and Experimental Therapeutics. 323 (1): 147–56. doi:10.1124/jpet.107.124701. PMID 17609420. S2CID 10402176.
Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX (June 2009). "Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism". Neuropsychopharmacology. 34 (7): 1783–96. doi:10.1038/npp.2008.236. PMC 3739975. PMID 19158667.

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