MAPK8

Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.[5][6]

MAPK8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 8
External IDsOMIM: 601158 MGI: 1346861 HomoloGene: 56760 GeneCards: MAPK8
Orthologs
SpeciesHumanMouse
Entrez

5599

26419

Ensembl

ENSG00000107643

ENSMUSG00000021936

UniProt

P45983

Q91Y86

RefSeq (mRNA)

NM_001310452
NM_001310453
NM_001310454
NM_016700

RefSeq (protein)

NP_001297381
NP_001297382
NP_001297383
NP_057909

Location (UCSC)Chr 10: 48.31 – 48.44 MbChr 14: 33.1 – 33.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported.[7] MAPK8 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[8]

Interactions

MAPK8 has been shown to interact with:

References
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  2. GRCm38: Ensembl release 89: ENSMUSG00000021936 - Ensembl, May 2017
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  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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  8. "JNK1 (human)". www.phosphosite.org. Retrieved 2020-10-28.
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Further reading

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