List of polysubstance combinations

Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations used entheogenic, or recreational, or off-label indicated use of pharmaceuticals; For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasially used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally.

Drug 1 Drug 2 Drug 3 Polysubstance slang,[2][3][4]
or brand name		 Intoxication name Comment
Any dissociative Any dissociative Void flip Void flipping
Any dissociative DMT Dime Bar, angel flip Dimension flipping, angel flipping
Any depressant Any stimulant Speedball, powerball, over and under Powerballing, speedballing[5]
Any pharmaceutical Any pharmaceutical Polypharmacy Pharming Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.[6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.[6]
Any drug Cannabis Amp joint[7]
Any drug Nicotine Cooler[5]
Any β-Carboline
containing plant (e.g.
Banisteriopsis caapi
or Peganum harmala)		 DMT Ayahuasca, Changa Ayahuasca is drunk. Changa is smoked or vaped.
Any deliriant, or diphenhydramine MDMA Nightmare flip Nightmare flipping
Antiretroviral drugs Black tar heroin Whoonga, Nyaope [8] Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone
2C-B LSD MDMA Ali flip [5] Ali flipping [9] This combination is a mix between a Candyflip & a Nexus flip
2C-B MDMA Nexus flip ,Honey flip[5] [10] Honey flipping, Nexus flipping The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+3)
2C-B DXM Nexuswalk[11] Nexuswalk Nexus (slang for 2C-B) + Robowalk (slang for walking on DXM), similar to Nexusflipping
2C-E LSD MDMA Haychmaich flip[5] Haychmaich flipping
2C-P 2C-E Meskini Trip Meskini Tripping
Alcohol Benzodiazepine Time flip Time flipping
Alcohol Caffeine Caffeinated alcoholic drink
Alcohol Cannabis Tincture of cannabis. Herb and Al. Judgement Day Cross fading, twisting, getting twisted[12] Called Judgement Day in Ghana when cannabis is added to the drink
Alcohol Cocaine Snow-cone Snow-coning Ethanol is metabolized into cocaethylene[13]
Alcohol MDMA Tipsy flip Tipsy flipping It may be dangerous
Alcohol Nicotine Nicotini A nicotini is any alcoholic drink which includes nicotine as an ingredient. Nicotine replacement therapy products such as mouth spray may be used.
Amphetamine Barbiturates Inbetweens[14]
Amphetamine Cannabis LSD Hippie heart attack
Amphetamine Cocaine Snow seals
Amphetamine Heroin Bombido[14]
Amphetamine Xanax Orange Dream Blossom Cloud Rush The combination is crushed together and insufflated
Belladonna Hashish Alamout black hash[5] Mixed
Caffeine Cannabis Hippie-speedball Hippie-speedballing
Caffeine Diphenhydramine Sleep walk Sleepwalking
Caffeine Methamphetamine Ya ba, biker's coffee, kamikaze
Cacao bean Magic mushroom Aztec use of entheogens. Conventional defatted cocoa solids dissolved in fat may be used instead of whole beans.
CBD THC Low to moderate doses of CBD might reduce some of the paranoia, anxiety,[15] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose.[16][17][18] Low doses of Kanna might also help counteract the anxiety.[19][20]
Cannabis Cocoa solids Cannabis-infused brownie Cannabis edible
Cannabis Crack cocaine Crack weed (less known: Buddha, caviar, champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, torpedo, turbo, wollie, yeola)[21] Cocoa puffs, splitting
Cannabis Crack cocaine Heroin Major Pronin, El Diablo
Cannabis Crack cocaine PCP Jim Jones
Cannabis Damiana Damiana and other herbs can be used as a tobacco alternative for rolling joints.[22]
Cannabis DXM Nicotine Candy blunt
Cannabis Heroin or opium A-bomb, Atom bomb, stuff[5]
Cannabis MDMA Stoner flip Stoner flipping
Cannabis Nicotine Blunt, joint, spliff A rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
Cannabis Opium Demetra
Cannabis PCP Wet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom) Illing Wet is cannabis dipped in PCP [23]
Cannabis PCP Nicotine Wet blunt, dust blunt, dusted blunt, Kendrick Lamar blunt Illing
Cocaine Heroin Snowball. Other names: Belushi, bombita, murder one, whiz bang Snowballing
Cocaine Heroin LSD Frisco special[5]
Cocaine Heroin Nicotine Flamethrower, primos Cigarette laced with cocaine and heroin
Cocaine Ketamine CK1, Calvin Klein, cable
Cocaine Ketamine MDMA Ketamollicaine
Cocaine LSD MDMA Candy-flip on a string Candy-flipping on a string High risk on health
Cocaine MDMA Sugar flip Sugar flipping
Cocaine Morphine C & M
Cocaine PCP Space, whack
Cocaine Wine Coca wine Ethanol is metabolized into cocaethylene
Cocaine Quetiapine Q-ball
Codeine Glutethimide Pancakes and syrups Combination of glutethimide and codeine cough syrup
Codeine Promethazine Lean, purple drank, oil
Crack cocaine Fentanyl Dirty fentanyl, takeover
Crack cocaine Heroin Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar
Crack cocaine LSD Cracid, outerlimits Cracid is a portmanteau of crack cocaine and acid
Crack cocaine Methamphetamine Fire, twisters
Crack cocaine Nicotine Coolie, crimmie, woolas A cigarette laced with crack
Crack cocaine Nicotine PCP Ozone PCP and crack cigarette
Crack cocaine PCP Missile base, P-funk, space base, spaceball, space cadet, space dust, tragic magic Missile basing, space basing
Diphenhydramine DXM OTC flip, counterflipping OTC flipping, robowalking on a string
DMT LSD Cosmo flip, Meadow flip Cosmo flipping, meadow flipping
DMT LSD Psilocybin or psilocybin mushroom Super flip Super flipping Take LSD and shrooms then at the come up smoke DMT
DMT MAOIs Pharmahuasca
DMT Psilocybin or psilocybin mushroom Terence flip Terence flipping
DMT Alcohol Spyder, Spinning, Spider Flip
DXM LSD LSDXM
DXM MDMA Robo flip Robo flipping
DXM Psilocybin or psilocybin mushroom Cherry-bomb Cherry-bombing
Fentanyl Heroin Birria, chiva loca, Facebook Facebook is mixed in a pill form
Fentanyl
(and/or heroin)		 Xylazine Tranq, Tranq dope "Tranq" is sometimes used to refer to xylazine by itself, but as a drug of abuse it is invariably combined with heroin or fentanyl
GHB MDMA Gamma flip Gamma flipping
GHB Methamphetamine Cherry meth
Hashish Crack cocaine Double zero
Hashish LSD Royal temple ball The hashish is mixed with LSD and rolled into a ball intended for oral use, because LSD cannot be smoked.
Hashish Opium Black hash, black Russian
Heroin Methamphetamine Goofball
Heroin Morphine New Jack swing
Heroin PCP Alien sex fiend[5]
Ketamine LSD Dolphin flip Dolphin flipping
Ketamine MDMA Kitty flip,[24] MK-ultra Kitty flipping
LSD Ketamine MDMA Holy Trident, Martin Luther King flip Holy Tridenting, Martin Luther King flipping
LSD MDMA Candy flip Candy flipping[5]
LSD MDMA Psilocybin or psilocybin mushroom Jedi flip,[24] twilight flip Jedi flipping, twilight flipping
LSD MDMA and Mushrooms Ketamine Quantum Flip Quantum Flipping Similar to Jedi flipping, but with a heavy dissociative effect induced by ketamine. The substances are taken in the order of LSD, Mushrooms, MDMA, then ketamine. Each substance should be taken at the peak of the previous substance to maximize the synergistic effects. Ketamine can be re-dosed as needed to extend the trip. The end result is a highly visual and euphoric experience with periods of deep dissociation.
LSD Mescaline Stella trip
LSD Nitrous oxide Gasid
LSD PCP Black acid
LSD Psilocybin or psilocybin mushroom God's flesh, Soul Bomb, Alice,[5] Wizard flip Wizard flipping
MDMA Any dissociative DMT Pixie flip Pixie flipping
MDMA Mescaline or psychoactive cactus Love flip, love trip Love flipping
MDMA Methadone Chocolate flip Chocolate flipping
MDMA Methamphetamine Trailer flip Trailer flipping
MDMA DMT Shaman flip, time flip Shaman flipping, time flipping
MDMA Nitrous oxide Nox
MDMA Opiates Poppy flip Poppy flipping
MDMA PCP Domex, elephant flip Elephant flipping
MDMA Psilocybin or psilocybin mushroom Žižkovflip Flippong the žižkov-hood
MDMA Methaqualone Disco flipping, Jelly flipping Troll Roll, Hippy flip[24] Hippy flipping[25]
MDMA Viagra (or other PDE5 inhibitors such as Cialis or Levitra) Sextacy
MDMA Xanax Zen flip Zen flipping
MDMA Ketamine Mushrooms Obama Flip Obama Flipping
Methamphetamine Secobarbital, or other barbiturates Poor man's speedball
Methamphetamine Alpha-PVP Cartel meth So-called "cartel meth" is primarily composed of cutting agents such as isopropylbenzylamine and/or dimethylsulfone with a small proportion of methamphetamine plus the potent stimulant Alpha-PVP
Nicotine PCP Chipping, fry cigarette
Pentazocine Tripelannamine T's and blues
Venlafaxine Mirtazepine California rocket fuel None of the drugs are illegal and the combination is used for medical purposes.

See also: Mixed drink § Polysubstance
Not to be confused with Lacing (drugs) § Commonly laced substances.
A drug combination chart designed for harm reduction by Tripsit[1].

See also

References
  1. https://combo.tripsit.me/
  2. "Erowid Drug Slang & Terminology Vault : A - B". erowid.org.
  3. Copping, Jasper (8 November 2009). "Drug slang: what police must learn A to B".
  4. https://ndews.umd.edu/sites/ndews.umd.edu/files/dea-drug-slang-terms-and-code-words-july2018.pdf
  5. "Erowid Drug Slang & Terminology Vault : A - B". erowid.org.
  6. Masnoon, Nashwa; Shakib, Sepehr; Kalisch-Ellett, Lisa; Caughey, Gillian E. (October 2017). "What is polypharmacy? A systematic review of definitions". BMC Geriatrics. 17 (1): 230. doi:10.1186/s12877-017-0621-2. ISSN 1471-2318. PMC 5635569. PMID 29017448.
  7. "Slang Terms for Drug Combinations". Narconon International. Retrieved 2021-12-08.
  8. Grelotti DJ, Closson EF, Smit JA, Mabude Z, Matthews LT, Safren SA, Bangsberg DR, Mimiaga MJ. Whoonga: potential recreational use of HIV antiretroviral medication in South Africa. AIDS Behav. 2014 Mar;18(3):511-8. doi:10.1007/s10461-013-0575-0 PMID 23955659
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  11. "DXM & 2C-B - Erowid Exp - 'Nexuswalk - A Beautiful Mix of DXM and 2C-B'". erowid.org. Retrieved 2023-04-18.
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  13. Pergolizzi, Joseph; Breve, Frank; Magnusson, Peter; LeQuang, Jo Ann K.; Varrassi, Giustino (2022-02-22). "Cocaethylene: When Cocaine and Alcohol Are Taken Together". Cureus. 14 (2): e22498. doi:10.7759/cureus.22498. ISSN 2168-8184. PMC 8956485. PMID 35345678.
  14. Keup, Wolfram (June 1971). "The Vocabulary of the Drug User and Alcoholic: A Glossary". The International Journal of the Addictions. 6 (2): 348. doi:10.3109/10826087109057793. PMID 4950517. Retrieved 7 October 2021.
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  16. Stuyt, Elizabeth (2018). "The Problem with the Current High Potency THC Marijuana from the Perspective of an Addiction Psychiatrist". Missouri Medicine. 115 (6): 482–486. ISSN 0026-6620. PMC 6312155. PMID 30643324.
  17. ElSohly, Mahmoud A.; Mehmedic, Zlatko; Foster, Susan; Gon, Chandrani; Chandra, Suman; Church, James C. (2016-04-01). "Changes in Cannabis Potency over the Last Two Decades (1995-2014) - Analysis of Current Data in the United States". Biological Psychiatry. 79 (7): 613–619. doi:10.1016/j.biopsych.2016.01.004. ISSN 0006-3223. PMC 4987131. PMID 26903403.
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