Keratin 34
Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.[5][6][7][8]
| KRT34 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | KRT34, HA4, Ha-4, KRTHA4, hHa4, Keratin 34, K34 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602763 MGI: 1309994 HomoloGene: 31083 GeneCards: KRT34 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[8]
See also
- 34βE12 (keratin 903)
References
- ENSG00000262045 GRCh38: Ensembl release 89: ENSG00000131737, ENSG00000262045 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000043485 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID 2431943.
- Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
- Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
- "Entrez Gene: KRT34 keratin 34".
Further reading
- Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Raica M, Zylis D, Cîmpean AM (2007). "Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma". Romanian Journal of Morphology and Embryology. 46 (1): 11–5. PMID 16286979.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
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