KCNJ16
Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the Kir5.1 protein.[5]
| KCNJ16 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | KCNJ16, BIR9, KIR5.1, potassium voltage-gated channel subfamily J member 16, potassium inwardly rectifying channel subfamily J member 16, HKTD | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605722 MGI: 1314842 HomoloGene: 23112 GeneCards: KCNJ16 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir5.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir5.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the regulation of fluid and pH balance. Three transcript variants encoding the same protein have been found for this gene.[5]
References
- GRCh38: Ensembl release 89: ENSG00000153822 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000051497 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: KCNJ16 potassium inwardly-rectifying channel, subfamily J, member 16".
Further reading
- Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Pearson WL, Dourado M, Schreiber M, et al. (1999). "Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver". J. Physiol. 514 ( Pt 3) (3): 639–53. doi:10.1111/j.1469-7793.1999.639ad.x. PMC 2269105. PMID 9882736.
- Liu Y, McKenna E, Figueroa DJ, et al. (2000). "The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas". Cytogenet. Cell Genet. 90 (1–2): 60–3. doi:10.1159/000015662. PMID 11060447. S2CID 26933916.
- Derst C, Karschin C, Wischmeyer E, et al. (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146. S2CID 14452157.
- Pessia M, Imbrici P, D'Adamo MC, et al. (2001). "Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1". J. Physiol. 532 (Pt 2): 359–67. doi:10.1111/j.1469-7793.2001.0359f.x. PMC 2278540. PMID 11306656.
- Tanemoto M, Fujita A, Higashi K, Kurachi Y (2002). "PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain". Neuron. 34 (3): 387–97. doi:10.1016/S0896-6273(02)00675-X. PMID 11988170. S2CID 15862428.
- Konstas AA, Korbmacher C, Tucker SJ (2003). "Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels". Am. J. Physiol., Cell Physiol. 284 (4): C910–7. doi:10.1152/ajpcell.00479.2002. PMID 12456399. S2CID 2525019.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Casamassima M, D'Adamo MC, Pessia M, Tucker SJ (2003). "Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels". J. Biol. Chem. 278 (44): 43533–40. doi:10.1074/jbc.M306596200. PMID 12923169.
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