HLA-DR18
HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.
 | |
major histocompatibility complex, class II, DR18 | |
| Haplotypes groups | DRA*01:DRB1*0302 DRA*01:DRB5*0303 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *0302 *0303 |
| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB5*0302 |
| EBI-HLA | DRB1*0303 |
| Shared data | |
| Locus | chr.6 6p21.31 |
Serology
| DRB1* | DR18 | DR3 | DR17 | Sample |
| allele | % | % | % | size (N) |
| 0302 | 66 | 24 | 3 | 317 |
| 0303 | 60 | 40 | 5 | |
DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3.
Disease associations
DR18 seropositivity is associated with rheumatoid polyarthritis[2]
DRB1*0302 is positively associated with juvenile diabetes,[3] nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.[4]
Genetic Linkage
DR18 Haplotypes | |||
| Serotypes | DRA | DRB1 | DRB3 |
|---|---|---|---|
| DR18(3)-DR52 | *0101 | *0302 | *0101 |
| DQA1 | DQB1 | DRB1 | |
| D18(3)-DQ2(2.5) | *0501 | *0201 | *0302 |
| HLA-A | HLA -B | DRB1 | |
| A33-B58-DR18(3) | *3301 | *5801 | *0302 |
HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.
References
- derived from IMGT/HLA
- Dieye A, Diallo S, Diatta M, Thiam A, Ndiaye R, Bao O, Sarthou J (1997). "[Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal]". Dakar Med. 42 (2): 111–3. PMID 9827131.
- Shawkatova I, Michalkova D, Barak L, Fazekasova H, Kuba D, Buc M (2006). "HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients". Bratislavské Lekárske Listy. 107 (3): 76–9. PMID 16796128.
- Sivakumar K, Semino-Mora C, Dalakas MC (1997). "An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families". Brain. 120 ( Pt 4) (4): 653–661. doi:10.1093/brain/120.4.653. PMID 9153127.
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