FOSL2

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.[5]

FOSL2
Identifiers
AliasesFOSL2, Fos-Related Antigen, FRA-2, FRA2, FOS like 2, AP-1 transcription factor subunit
External IDsOMIM: 601575 MGI: 102858 HomoloGene: 3845 GeneCards: FOSL2
Orthologs
SpeciesHumanMouse
Entrez

2355

14284

Ensembl

ENSG00000075426

ENSMUSG00000029135

UniProt

P15408

P47930

RefSeq (mRNA)

NM_005253

NM_008037

RefSeq (protein)

NP_005244

NP_032063

Location (UCSC)Chr 2: 28.39 – 28.42 MbChr 5: 32.29 – 32.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000075426 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029135 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FOSL2 FOS-like antigen 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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