Flavokavain B

Flavokavain B is a flavokavain found in the kava plant.[1] In 2010 a paper was published identifying it as a glutathione-depleting hepatotoxin.[2]

Flavokavain B
Names
Preferred IUPAC name
2′-Hydroxy-4′,6′-dimethoxychalcone
Other names
Flavokawain B
Identifiers
3D model (JSmol)
2059845
UNII
  • O=C(C2=C(O)C=C(OC)C=C2OC)/C=C/C1=CC=CC=C1
Properties
C17H16O4
Molar mass 284.311 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

FKB is said by enthusiasts to occur at higher concentrations in "tudei" kava strains, which are generally considered less desirable.

See also

References
  1. Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry. 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.
  2. Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S.X 'Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732)


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