FGR (gene)

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[5][6]

FGR
Identifiers
AliasesFGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, FGR proto-oncogene, Src family tyrosine kinase
External IDsOMIM: 164940 MGI: 95527 HomoloGene: 3842 GeneCards: FGR
Orthologs
SpeciesHumanMouse
Entrez

2268

14191

Ensembl

ENSG00000000938

ENSMUSG00000028874

UniProt

P09769

P14234

RefSeq (mRNA)

NM_001042729
NM_001042747
NM_005248

NM_010208

RefSeq (protein)

NP_001036194
NP_001036212
NP_005239

NP_034338

Location (UCSC)Chr 1: 27.61 – 27.64 MbChr 4: 132.7 – 132.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein–Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[6]

Discovery

The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[7]

Interactions

FGR (gene) has been shown to interact with Wiskott–Aldrich syndrome protein.[8][9][10]

References
  1. GRCh38: Ensembl release 89: ENSG00000000938 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028874 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6595–9. Bibcode:1985PNAS...82.6595T. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
  6. "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".
  7. Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.
  8. Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I (Aug 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Current Biology. 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. PMID 8805332. S2CID 162267.
  9. Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S (Oct 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains" (PDF). The Journal of Biological Chemistry. 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. PMID 8824280. S2CID 1945958.
  10. Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (Oct 1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology. 15 (10): 5725–31. doi:10.1128/MCB.15.10.5725. PMC 230823. PMID 7565724.

Further reading


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