Donovan's solution

Donovan's solution is an inorganic compound prepared from arsenic triiodide and mercuric iodide.[1] Despite its name, it is a compound and not a solution.

Donovan's Solution
Names
IUPAC name
Iodomercury; triiodoarsane
Other names
Liquor hydriodatis arsenici et hydrargyri
Identifiers
3D model (JSmol)
ChemSpider
RTECS number
  • CG3200000
UN number 1557
  • InChI=1S/AsI3.Hg.HI/c2-1(3)4;;/h;;1H/q;+1;/p-1
    Key: QLULWSBMTZWVDE-UHFFFAOYSA-M
  • [As](I)(I)I.I[Hg]
Properties
AsHgI4
Molar mass 783.12948
Appearance Clear, colourless, or pale yellow. Darkens with age.
Boiling point 403 °C (757 °F; 676 K) at 760 mmHg
Yes
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Toxic
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Method

Donovan's solution can be prepared by mixing arsenic triiodide, mercuric iodide, and sodium bicarbonate in aqueous solution.[2][3]

Cooley's cyclopædia of practical receipts and ... information on the arts, manufactures, and trades gives a more complex method.[4]

Uses

The solution been used in veterinary medicine to treat chronic diseases of the skin[3] and as a folk remedy.[5] It was used during the 19th century to treat lepra vulgaris[6] and psoriasis[7][8] in humans, taken internally.

References
  1. Budavari, Susan (1989). "3413. Donovan's Solution". The Merck Index (11th ed.). Merck & Co., Inc. p. 537. ISBN 091191028X. LCCN 89060001.
  2. Navy Department. Bureau of Medicine and Surgery (1950). Pharmacy and Materia Medica: Military-medical Operations Courses. Bureau of Naval Personnel. p. 17.
  3. Oxtoby, David W.; H.P. Gillis; Allan Campion (2012). Principles of modern chemistry (7th ed.). Belmont, Calif.: Brooks/Cole Cengage Learning. p. 513. ISBN 978-0840049315.
  4. Arnold James Cooley (1880). "Solution". In Richard Vine Tuson (ed.). A cyclopædia of practical receipts and ... information on the arts, manufactures, and trades. Vol. II (6th ed.). p. 1525.
  5. "Donovan's solution". Chemical Dictionary Online. Retrieved 29 November 2013.
  6. Sir Erasmus Wilson (1847). "Treatment of Lepra". On Diseases of the Skin (2nd ed.). John Churchill. p. 271.
  7. Henry G. Piffard (1881). "Psoriasis Treatment. Part 6". A Treatise On The Materia Medica And Therapeutics Of The Skin. Sampson, Low, Marston, Searle & Rivington. p. 254.
  8. "Good Results of Donovan's Solution in Psoriasis". The Lancet. 70 (1770): 116. August 1857. doi:10.1016/S0140-6736(02)38789-0.


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