Cunninghamella

Cunninghamella is a genus of fungi in the order Mucorales, and the family Cunninghamellaceae.[2] The genus was circumscribed by French mycologist Alphonse Louis Paul Matruchot in Ann. Mycol. Vol.1 on page 47 in 1903.[3]

Cunninghamella
"Cunninghamella echinulata"
Cunninghamella echinulata
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Fungi
Division: Mucoromycota
Order: Mucorales
Family: Cunninghamellaceae
Genus: Cunninghamella
Matr. (1903)
Type species
Cunninghamella africana
Matr. 1903
Species

See text

Synonyms[1]
  • Actinocephalum Saito (1905)
  • Muratella Bainier & Sartory (1913)
  • Saitomyces Ricker (1906)

The genus name of Cunninghamella is in honour of David Douglas Cunningham (1843–1914), who was a Scottish doctor and researcher who worked extensively in India on various aspects of public health and medicine.[4]

Species

As of  2015, Index Fungorum lists 13 valid species of Cunninghamella:[5]

Uses

Members of this genus are often used in studies investigating the metabolism of drugs, because these species metabolize a wide range of drugs in manners similar to mammalian enzyme systems.[6] Many species are also capable of oxidizing polycyclic aromatic hydrocarbons, a class of stable organic molecules that tends to persist in the environment and contains many known carcinogenic and mutagenic compounds.[7]

The presence of a cytochrome P450 has been demonstrated in C. bainieri.[8]

References
  1. "Synonymy: Cunninghamella Matr". Species Fungorum. CAB International. Retrieved 21 September 2015.
  2. Cunninghamella at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  3. Matruchot L. (1903). "Une Mucorinée purement conidienne. Cunninghamella africana". Annales Mycologici (in French). 1: 45–60.
  4. Burkhardt, Lotte (2022). Eine Enzyklopädie zu eponymischen Pflanzennamen [Encyclopedia of eponymic plant names] (pdf) (in German). Berlin: Botanic Garden and Botanical Museum, Freie Universität Berlin. doi:10.3372/epolist2022. ISBN 978-3-946292-41-8. S2CID 246307410. Retrieved 27 January 2022.
  5. "Species Fungorum (version 26th August 2015). In: Species 2000 & ITIS Catalogue of Life". Retrieved 21 September 2015.
  6. Asha S, Vidyavathi M (2009). "Cunninghamella--a microbial model for drug metabolism studies--a review". Biotechnol. Adv. 27 (1): 16–29. doi:10.1016/j.biotechadv.2008.07.005. PMID 18775773.
  7. Cerniglia, Carl E. (1992). "Biodegradation of polycyclic aromatic hydrocarbons". Biodegradation. 3 (2–3): 351–368. doi:10.1007/BF00129093. S2CID 25516145.
  8. Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri: Evidence for the presence of cytochrome P-450. J.P. Ferris, L.H. MacDonald, M.A. Patrie and M.A. Martin, Archives of Biochemistry and Biophysics, Volume 175, Issue 2, August 1976, pages 443-452, doi:10.1016/0003-9861(76)90532-4


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