Clocinnamox

Clocinnamox is a selective, irreversible μ-opioid receptor antagonist.[1]

Clocinnamox
Names
Preferred IUPAC name
(2E)-3-(4-Chlorophenyl)-N-[(4R,4aS,7aR,12bR)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methano[1]benzofuro[3,2-e]isoquinolin-4a-yl]prop-2-enamide
Other names
Chlorocinnamoylaminodihydronormorphinone
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C29H29ClN2O4/c30-20-7-3-17(4-8-20)5-10-24(35)31-29-12-11-22(34)27-28(29)13-14-32(16-18-1-2-18)23(29)15-19-6-9-21(33)26(36-27)25(19)28/h3-10,18,23,27,33H,1-2,11-16H2,(H,31,35)/b10-5+/t23-,27+,28+,29-/m1/s1
    Key: RAURUSFBVQLAPW-DNIKMYEQSA-N
  • C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)NC(=O)/C=C/C7=CC=C(C=C7)Cl
Properties
C29H29ClN2O4
Molar mass 505.01 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Filho, CB; Del Fabbro, L; De Gomes, MG; Goes, AT; Souza, LC; Boeira, SP; Jesse, CR (2013). "Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test". European Journal of Pharmacology. 698 (1–3): 286–91. doi:10.1016/j.ejphar.2012.11.003. PMID 23178563.


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