CXCL15

Cxcl15
Identifiers
Aliases	chemokine (C-X-C motif) ligand 15Il8Scyb15lungkineweche
External IDs	GeneCards:
Gene location (Human)
Chr.	Chromosome 5 (human)
End	90,950,926 bp
RNA expression pattern
	Top expressed in
	left lung lobe; ; right lung lobe; ; trachea; ; cervix; ; sexually immature organism; ; mammary gland; ; external carotid artery; ; nucleus accumbens; ; carotid body; ; urinary bladder;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	chemokine activity; cytokine activity; CXCR3 chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	chemotaxis; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; response to lipopolysaccharide; inflammatory response; regulation of cell population proliferation; immune response; neutrophil chemotaxis; positive regulation of leukocyte chemotaxis; defense response; T cell chemotaxis; regulation of signaling receptor activity; hemopoiesis; leukocyte chemotaxis; antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	20309
	n/a
	ENSMUSG00000029375
	n/a
	Q9WVL7
	n/a
	NM_011339
	n/a
	NP_035469
	n/a
	Wikidata
View/Edit Human

Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,[2] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.[3] The gene for CXCL15 is found on mouse chromosome 5.

References

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol. 162 (9): 5490–7. PMID 10228029.
Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem. 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol. 162 (9): 5490–7. PMID 10228029.

[3] Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem. 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.