c-ANCA

c-ANCAs, or PR3-ANCA, or antineutrophil cytoplasmic antibodies, are a type of autoantibody, an antibody produced by the body that acts against one of its own proteins. These antibodies show a diffusely granular, cytoplasmic staining pattern under microscopy. This pattern results from binding of ANCAs to antigen targets throughout the neutrophil cytoplasm, the most common protein target being proteinase 3 (PR3). For example, PR3 is the most common antigen target of ANCA in patients with granulomatosis with polyangiitis. In active granulomatosis with polyangiitis, c-ANCA is found over 90% of the time.[1] Other antigens may also occasionally result in a c-ANCA pattern.

The granular, cytoplasmic staining pattern of c-ANCA

References

Thomas M. Habermann (26 June 2006). Mayo Clinic internal medicine review, 2006-2007. CRC Press. pp. 935–. ISBN 978-0-8493-9059-3. Retrieved 1 November 2010.

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[Habermann2006-1] Thomas M. Habermann (26 June 2006). Mayo Clinic internal medicine review, 2006-2007. CRC Press. pp. 935–. ISBN 978-0-8493-9059-3. Retrieved 1 November 2010.

Autoantibodies
Anti-nuclear antibody	PBC: Anti-gp210 Anti-p62 Anti-sp100 ENA: Anti-topoisomerase/Scl-70 Anti-Jo1 ENA4 Anti-Sm Anti-nRNP Anti-Ro Anti-La Anti-centromere Anti-dsDNA Anti-histone
Anti-mitochondrial antibody	Anti-cardiolipin
Anti-cytoplasm antibody	Anti-neutrophil cytoplasmic C-ANCA P-ANCA Anti-smooth muscle Anti-actin Anti-TPO/Antimicrosomal
Cell membrane	Anti-ganglioside Anti-GBM Anti-glutamate
Extracellular	Anti-thrombin Lupus anticoagulant Coeliac disease: Anti-transglutaminase Anti-gliadin not autoantibody RA Rheumatoid factor Anti-citrullinated peptide
Multiple locations	Anti-phospholipid Anti-apolipoprotein

c-ANCA

See also

References