Ashwani Kumar (scientist)

Ashwani Kumar is an Indian microbiologist and the Senior Principal Scientist at the Institute of Microbial Technology (ImTech). He is known for his studies on Mycobacterium tuberculosis, the causative agent of tuberculosis. His laboratory focuses on understanding the reasons for drug tolerance observed in humans. His laboratory hypothesizes that tuberculosis is a biofilm infection, so its treatment needs the administration of multiple drugs for at least six months. The Department of Science and Technology has awarded him Swarnajayanti Fellowship for 2016–2017. Department of Biotechnology has awarded him the National Bioscience Prize (2017-18). He was also selected for DBT/Wellcome Trust India Alliance Senior Fellowship (2021 to 2026). He was elected as a Fellow of the National Academy of Sciences, India, in 2022. For his contributions in tuberculosis pathogenesis, he was awarded with Shanti Swarup Bhatnagar Prize for Science and Technology 2022. He is considered as one of India's Leading Scientist in the field of Tuberculosis and his lab is doing some of the best research in India.

This article is about the scientist. For other people with a similar name, see Ashwani Kumar.
Ashwani Kumar
Born
New Delhi, India
Alma materUniversity of Delhi & University of Alabama at Birmingham
Known forStudies on Mycobacterium tuberculosis
AwardsShanti Swarup Bhatnagar Prize for Science and Technology 2022. DBT/Wellcome Trust India Alliance Senior Fellowship (2021 to 2026). 2017–18 N-BIOS Prize. 2016 DST Swarnajayanti Fellowship
Scientific career
Fields
Institutions
Doctoral advisorProf. Vani Brahmachari and Prof. Mridula Bose

Biography

Ashwani Kumar is a Senior Principal Scientist at the Institute of Microbial Technology (ImTech)[1] where he heads a laboratory, popularly known as Ashwani Kumar's Lab.[2] and serves as a principal investigator.[3] He is known to have done extensive research on Mycobacterium tuberculosis and has served as a member of MDRIpred project,[4] an open source server for predicting inhibitors against drug-tolerant M.tb H37Rv.[5] He has published a number of articles;[6] ResearchGate, an online repository of scientific articles has listed 31 of them.[7] His laboratory has demonstrated the presence of cellulose encased biofilms[8] inside the hosts including human.[9] He also works on regulation of autophagy by signalling gases such as carbon monoxide[10] and hydrogen sulfide.[11] The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for him contributions to biosciences, in 2017–18.[12]

Selected bibliography

Articles

See also

References
  1. "Ashwani Kumar - ImTech profile". Institute of Microbial Technology. 2019-01-14. Retrieved 2019-01-14.
  2. "Ashwani Kumar's lab - Institute of Microbial Technology (IMTECH)". ResearchGate. 2019-01-14. Retrieved 2019-01-14.
  3. "Addgene: Ashwani Kumar Lab Plasmids". www.addgene.org. 2019-01-14. Retrieved 2019-01-14.
  4. "MDRIpred: A webserver for predicting inhibitors against drug resistant M.Tuberculosis". crdd.osdd.net. 2019-01-14. Retrieved 2019-01-14.
  5. "Welcome to MDRIpred". crdd.osdd.net. 2019-01-14. Retrieved 2019-01-14.
  6. "Ashwani Kumar - Google Scholar Citations". scholar.google.com. 2019-01-14. Retrieved 2019-01-14.
  7. "Ashwani Kumar Institute of Microbial Technology - IMTECH · Molecular Mycobacteriology 28 36 ·". ResearchGate. 2019-01-14. Retrieved 2019-01-14.
  8. Trivedi, Abhishek; Mavi, Parminder Singh; Bhatt, Deepak; Kumar, Ashwani (September 2016). "Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis". Nature Communications. 7 (1): 11392. Bibcode:2016NatCo...711392T. doi:10.1038/ncomms11392. ISSN 2041-1723. PMC 4848537. PMID 27109928.
  9. Chakraborty, Poushali; Bajeli, Sapna; Kaushal, Deepak; Radotra, Bishan Dass; Kumar, Ashwani (2021-03-11). "Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis". Nature Communications. 12 (1): 1606. doi:10.1038/s41467-021-21748-6. ISSN 2041-1723. PMC 7952908. PMID 33707445.
  10. Singh, Nisha; Kansal, Pallavi; Ahmad, Zeeshan; Baid, Navin; Kushwaha, Hariom; Khatri, Neeraj; Kumar, Ashwani (2018-06-03). "Antimycobacterial effect of IFNG (interferon gamma)-induced autophagy depends on HMOX1 (heme oxygenase 1)-mediated increase in intracellular calcium levels and modulation of PPP3/calcineurin-TFEB (transcription factor EB) axis". Autophagy. 14 (6): 972–991. doi:10.1080/15548627.2018.1436936. ISSN 1554-8627. PMC 6103408. PMID 29457983.
  11. Iqbal, Iram Khan; Bajeli, Sapna; Sahu, Shivani; Bhat, Shabir Ahmad; Kumar, Ashwani (2021-01-18). "Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy". Autophagy. 17 (11): 3511–3529. doi:10.1080/15548627.2021.1876342. ISSN 1554-8627. PMC 8632308. PMID 33459133. S2CID 231636126.
  12. "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2019. Archived from the original (PDF) on 2018-12-26. Retrieved 2017-11-20.
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