Andrew McMichael

Sir Andrew James McMichael, FRS FMedSci KBE (born 8 November 1943) is an immunologist, Professor of Molecular Medicine, and previously Director of the Weatherall Institute of Molecular Medicine at the University of Oxford. He is particularly known for his work on T cell responses to viral infections such as influenza and HIV.

Andrew McMichael

FRS FMedSci KBE
Born8 November 1943 Edit this on Wikidata (age 79)
London Edit this on Wikidata
Alma mater
Occupation
Parent(s)
Academic career
FieldsImmunology, medicine, molecular medicine Edit this on Wikidata
Institutions
ThesisThe clonal expression of antibody-forming cells.
Doctoral advisorBrigitte Askonas
Academic advisorHugh McDevitt
Doctoral studentsMalegapuru William Makgoba, Suranjith Seneviratne

Early life and education

McMichael was born in London on 8 November 1943 to Sir John McMichael and Joan Catherine.[1] He went to school at St Pauls and then to the University of Cambridge at Gonville and Caius College to study medicine (1962–1968).[2] He went on to complete a PhD at the National Institute for Medical Research supervised by 'Ita' Brigitte Askonas and Alan Williamson. His thesis, published in 1975, is entitled The clonal expression of antibody-forming cells.[3]

Career and research

After his PhD McMichael completed his postdoctoral research supervised by Hugh McDevitt at Stanford University.[4] In 1977 he returned to the UK to study the T cell response to HIV infection. His research group have created two HIV vaccines which were tested in phase I clinical trials.[5] McMichael became director of the Weatherall Institute of Molecular Medicine in 2000, and remained so until 2012.[6] He founded the MRC Human Immunology Unit in 1998 as honorary director until 2010.

McMichael has supervised over 55 DPhil students over his career,[5] many of whom have gone on to become leading immunologists themselves:

  • Douglas F. Nixon, Professor of Immunology in Medicine, Weill Cornell Medical College.[7][8]
  • Malegapuru Makgoba, Professor of Immunology and former Vice-Chancellor & Principal of the University of KwaZulu-Natal.[9]
  • Matilu Mwau Professor and Executive Director of the Consortium for National Health Research[10][11]
  • Paul Bowness, Professor of Experimental Rheymatology[12][13]
  • Awen Gallimore, Professor of Cancer Immunology[14][15][16]
  • Paul Klenerman, Sidney Truelove Professor of Gastroenterology[17][18][19]
  • Dan Barouch, Professor of Medicine and Director of the Center for Virology and Vaccine Research at Harvard Medical School[20][21]
  • Sophie Hambleton, Professor of Paediatrics & Immunology[22][23][24]
  • Suranjith Seneviratne, Professor, Director of the Centre for Mast Cell Disorders and the President of the UK-Sri Lanka Immunology Foundation.[25][26][27]
  • Ling-Pei Ho, Professor of Respiratory Immunology[28][29]

In addition McMichael supervised postdoctoral researchers, including Tomáš Hanke (Professor of Vaccine Immunology), and Sarah Rowland-Jones (Professor of Immunology).[30][31][32][33]

Awards and honours

Personal life

In 1968 McMichael married Kathryn 'Kate' Elizabeth Cross, they have two sons and one daughter.[2] McMichael enjoys walking and skiing at his house in La Salle les Alpes, France.[2]

Notable works

McMichael, A. J.; Ting, A.; Zweerink, H. J.; Askonas, Brigitte A. (1977). "HLA restriction of cell-mediated lysis of influenza virus-infected human cells". Nature. 270 (5637): 524–526. Bibcode:1977Natur.270..524M. doi:10.1038/270524a0. ISSN 1476-4687. PMID 593371. S2CID 4173925.

McMichael, A. J.; Gotch, F. M.; Noble, G. R.; Beare, P. A. (7 July 1983). "Cytotoxic T-cell immunity to influenza". The New England Journal of Medicine. 309 (1): 13–17. doi:10.1056/NEJM198307073090103. ISSN 0028-4793. PMID 6602294.

Townsend, A. R.; Rothbard, J.; Gotch, F. M.; Bahadur, G.; Wraith, D.; McMichael, A. J. (28 March 1986). "The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides". Cell. 44 (6): 959–968. doi:10.1016/0092-8674(86)90019-x. ISSN 0092-8674. PMID 2420472. S2CID 23606100.

Phillips, R. E.; Rowland-Jones, S.; Nixon, D. F.; Gotch, F. M.; Edwards, J. P.; Ogunlesi, A. O.; Elvin, J. G.; Rothbard, J. A.; Bangham, C. R. (12 December 1991). "Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition". Nature. 354 (6353): 453–459. Bibcode:1991Natur.354..453P. doi:10.1038/354453a0. ISSN 0028-0836. PMID 1721107. S2CID 4257933.

Altman, J. D.; Moss, P. A.; Goulder, P. J.; Barouch, D. H.; McHeyzer-Williams, M. G.; Bell, J. I.; McMichael, A. J.; Davis, M. M. (4 October 1996). "Phenotypic analysis of antigen-specific T lymphocytes". Science. 274 (5284): 94–96. Bibcode:1996Sci...274...94A. doi:10.1126/science.274.5284.94. ISSN 0036-8075. PMID 8810254. S2CID 12667633.

Goonetilleke, Nilu; Liu, Michael K. P.; Salazar-Gonzalez, Jesus F.; Ferrari, Guido; Giorgi, Elena; Ganusov, Vitaly V.; Keele, Brandon F.; Learn, Gerald H.; Turnbull, Emma L. (8 June 2009). "The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection". The Journal of Experimental Medicine. 206 (6): 1253–1272. doi:10.1084/jem.20090365. ISSN 1540-9538. PMC 2715063. PMID 19487423.

Liu, Michael K. P.; Hawkins, Natalie; Ritchie, Adam J.; Ganusov, Vitaly V.; Whale, Victoria; Brackenridge, Simon; Li, Hui; Pavlicek, Jeffrey W.; Cai, Fangping (January 2013). "Vertical T cell immunodominance and epitope entropy determine HIV-1 escape". The Journal of Clinical Investigation. 123 (1): 380–393. doi:10.1172/JCI65330. ISSN 1558-8238. PMC 3533301. PMID 23221345.

Fellay, Jacques; Shianna, Kevin V.; Ge, Dongliang; Colombo, Sara; Ledergerber, Bruno; Weale, Mike; Zhang, Kunlin; Gumbs, Curtis; Castagna, Antonella (17 August 2007). "A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1". Science. 317 (5840): 944–947. Bibcode:2007Sci...317..944F. doi:10.1126/science.1143767. ISSN 0036-8075. PMC 1991296. PMID 17641165.

Hill, Adrian V. S.; Allsopp, Catherine E. M.; Kwiatkowski, Dominic; Anstey, Nicholas M.; Twumasi, Patrick; Rowe, Pamela A.; Bennett, Stephen; Brewster, David; McMichael, Andrew J. (1991). "Common West African HLA antigens are associated with protection from severe malaria". Nature. 352 (6336): 595–600. Bibcode:1991Natur.352..595H. doi:10.1038/352595a0. ISSN 1476-4687. PMID 1865923.

Braud, Veronique M.; Allan, David S. J.; O'Callaghan, Christopher A.; Söderström, Kalle; D'Andrea, Annalisa; Ogg, Graham S.; Lazetic, Sasha; Young, Neil T.; Bell, John I. (1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature. 391 (6669): 795–799. Bibcode:1998Natur.391..795B. doi:10.1038/35869. ISSN 1476-4687. PMID 9486650. S2CID 4379457.

McMichael, Andrew J.; Rowland-Jones, Sarah L. (19 April 2001). "Cellular immune responses to HIV". Nature. 410 (6831): 980–987. Bibcode:2001Natur.410..980M. doi:10.1038/35073658. PMID 11309628.

Appay, Victor; Dunbar, P. Rod; Callan, Margaret; Klenerman, Paul; Gillespie, Geraldine M.A.; Papagno, Laura; Ogg, Graham S.; King, Abigail; Lechner, Franziska (2002). "Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections". Nature Medicine. 8 (4): 379–385. doi:10.1038/nm0402-379. ISSN 1546-170X. PMID 11927944. S2CID 22346636.

McMichael, Andrew J.; Borrow, Persephone; Tomaras, Georgia D.; Goonetilleke, Nilu; Haynes, Barton F. (2010). "The immune response during acute HIV-1 infection: clues for vaccine development". Nature Reviews Immunology. 10 (1): 11–23. doi:10.1038/nri2674. ISSN 1474-1741. PMC 3119211. PMID 20010788.

References
  1. "McMichael, Sir Andrew (James)". Who's Who. Oxford University Press. December 2007. doi:10.1093/ww/9780199540884.013.U26104. ISBN 978-0-19-954088-4.
  2. Vetta, Sylvia (June 2014). "Sylvia Vetta meets Professor Sir Andrew McMichael, Oxford University Professor of Molecular Medicine" (PDF). Retrieved 11 February 2018.
  3. McMichael, A. J. (1975). The clonal expression of antibody-forming cells (Ph.D. thesis). England: Council for National Academic Awards (United Kingdom). ProQuest 301272025.
  4. "Interview with leading HIV vaccine researcher - Prof. Sir Andrew McMichael - 80,000 Hours". 80,000 Hours. 28 January 2014. Retrieved 11 February 2018.
  5. "Andrew McMichael: Some final words - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 11 February 2018.
  6. "Jenner Institute News" (PDF). May 2013. Retrieved 11 February 2018.
  7. Nixon, Douglas F. (1990). Cytotoxic T cell immunity in HIV infection (Thesis). Thesis DPhil--University of Oxford.
  8. "Nixon, Douglas".
  9. Makgoba, M. W. (1983). Studies on the polymorphism of HLA class II antigens (Thesis). Thesis DPhil--University of Oxford.
  10. Mwau, Matilu (2004). Clinical evaluation of a candidate HIV-1 Clade A DNA/MVA vaccine designed for Kenya (Thesis). Thesis DPhil--University of Oxford.
  11. "Prof. Matilu Mwau – Consortium for National Health Research". www.keshop.co.ke. Archived from the original on 12 February 2018. Retrieved 11 February 2018.
  12. Bowness, Paul (1993). Recognition of antigen and superantigen by cytotoxic lymphocytes (Thesis). Thesis DPhil--University of Oxford.
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  14. Gallimore, Awen M. (1994). Simian immunodeficiency virus: specific cytotoxic T cell responses in cynomolgus macaques (Thesis). Thesis DPhil--University of Oxford.
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  17. Klenerman, Paul (1995). Cytotoxic T cell antagonism in HIV infection (Thesis). Thesis DPhil--University of Oxford.
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  19. "paul Klenerman". Loop. Retrieved 12 February 2018.
  20. Barouch, Dan H. (1995). Peptide binding and presentation by HLA-A2 (Thesis). Thesis DPhil--University of Oxford.
  21. "Immunology Faculty Member - Dan Barouch, MD, PhD". Harvard Medical School. 14 July 2014.
  22. Hambleton, Sophie (2001). Notch and immunodominance in CD8+ T cell responses (Thesis). Thesis DPhil--University of Oxford.
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