2005–06 UEFA Cup first round
The first round of the 2005–06 UEFA Cup began on 15 September 2005, which narrowed clubs down to 40 teams in preparation for the group stage.
Seeding
    
Summary
    
First leg
    
All times CET
| APOEL .svg.png.webp) | 0–1 |  Hertha BSC | 
|---|---|---|
| Report | Marcelinho  92' (pen.) | 
| Baník Ostrava  | 2–0 |  Heerenveen | 
|---|---|---|
| Klimpl  28' Magera  45' (pen.) | Report | 
| Bayer Leverkusen  | 0–1 |  CSKA Sofia | 
|---|---|---|
| Report | Todorov  15' | 
| Bolton Wanderers  | 2–1 |  Lokomotiv Plovdiv | 
|---|---|---|
| Diouf  72' Borgetti  91' | Report | Jančevski  27' | 
| CSKA Moscow  | 3–1 |  Midtjylland | 
|---|---|---|
| Gusev  21' Carvalho  76', 79' | Report | Pimpong  24' | 
| Grasshoppers .svg.png.webp) | 1–1 |  MyPa | 
|---|---|---|
| Salatić  1' | Report | Marco Manso  19' | 
| Graz  | 0–2 |  Strasbourg | 
|---|---|---|
| Report | Pagis  1' Lacour  45' | 
| Vitória de Guimarães  | 3–0 |  Wisła Kraków | 
|---|---|---|
| Cléber  24' (pen.) Mário Sérgio  70' Benachour  72' | Report | 
| Halmstad  | 1–2 |  Sporting CP | 
|---|---|---|
| Þorvaldsson  42' (pen.) | Report | Wender  44' Deivid  47' | 
| Hamburg  | 1–1 |  Copenhagen | 
|---|---|---|
| Van der Vaart  37' | Report | Van Heerden  40' | 
| Krylya Sovetov Samara  | 5–3 |  AZ | 
|---|---|---|
| Leilton  11' Adamu  44' Kowba  49' Husin  63' Bober  90+2' | Report | Vlaar  18' Perez  56' Van Galen  85' | 
| Litex Lovech  | 2–2 | .svg.png.webp) Genk | 
|---|---|---|
| Venkov  65' Novaković  90+1' | Report | Daerden  53' Stojanović  85' | 
| Maccabi Petah Tikva  | 0–2 | .svg.png.webp) Partizan | 
|---|---|---|
| Report | Vukčević  33' Radonjić  46' | 
| Middlesbrough  | 2–0 |  Skoda Xanthi | 
|---|---|---|
| Boateng  28' Viduka  83' | Report | 
| PAOK  | 1–1 |  Metalurh Donetsk | 
|---|---|---|
| Salpingidis  25' | Report | Shyshchenko  66' | 
| Slavia Prague  | 2–0 |  Cork City | 
|---|---|---|
| Hrdlička  62' Piták  79' | Report | 
| Tromsø  | 1–0 |  Galatasaray | 
|---|---|---|
| Szekeres  77' | Report | 
| Viking  | 1–0 |  Austria Wien | 
|---|---|---|
| Mumba  71' | Report | 
| Vitória de Setúbal  | 1–1 | .svg.png.webp) Sampdoria | 
|---|---|---|
| Hempel  46' | Report | Flachi  14' | 
Second leg
    
All times CET
| Hertha BSC  | 3–1 | .svg.png.webp) APOEL | 
|---|---|---|
| Marcelinho  15' Rafael  25' Cairo  52' | Report | Makrides  76' | 
Hertha BSC won 4–1 on aggregate.
| Levski Sofia  | 1–0 |  Auxerre | 
|---|---|---|
| Koprivarov  28' | Report | 
2–2 on aggregate; Levski Sofia won on away goals.
| Heerenveen  | 5–0 |  Baník Ostrava | 
|---|---|---|
| Samaras  3' Nilsson  45' Huntelaar  60', 67' Yıldırım  66' | Report | 
Heerenveen won 5–2 on aggregate.
| Široki Brijeg  | 0–1 | .svg.png.webp) Basel | 
|---|---|---|
| Report | Petrić  8' | 
Basel won 6–0 on aggregate.
| CSKA Sofia  | 1–0 |  Bayer Leverkusen | 
|---|---|---|
| Hdiouad  67' | Report | 
CSKA Sofia won 2–0 on aggregate.
Beşiktaş won 4–2 on aggregate.
| Lokomotiv Plovdiv  | 1–2 |  Bolton Wanderers | 
|---|---|---|
| Iliev  52' | Report | Tunchev  79' (o.g.) Nolan  86' | 
Bolton Wanderers won 4–2 on aggregate.
Brøndby won 3–2 on aggregate.
| Braga  | 1–1 | .svg.png.webp) Red Star Belgrade | 
|---|---|---|
| Jaime Júnior  86' | Report | Purović  11' | 
1–1 on aggregate; Red Star Belgrade won on away goals.
| Midtjylland  | 1–3 |  CSKA Moscow | 
|---|---|---|
| D. Nielsen  14' | Report | Carvalho  61', 77' Samodin  76' | 
CSKA Moscow won 6–2 on aggregate.
| Everton  | 1–0 |  Dinamo București | 
|---|---|---|
| Cahill  28' | Report | 
Dinamo București won 5–2 on aggregate.
| Rapid București  | 1–0 |  Feyenoord | 
|---|---|---|
| Buga  12' | Report | 
Rapid București won 2–1 on aggregate.
Espanyol won 3–1 on aggregate.
| Marseille  | 0–0 (a.e.t.) | .svg.png.webp) Germinal Beerschot | 
|---|---|---|
| Report | ||
| Penalties | ||
| Giménez  André Luís  Taiwo  Nasri  | 4–1 |  Öztürk  Chimedza  Agyeman | 
0–0 on aggregate; Marseille won 4–1 on penalties.
Grasshoppers won 4–1 on aggregate.
Strasbourg won 7–0 on aggregate.
Vitória de Guimarães won 4–0 on aggregate.
| Sporting CP  | 2–3 (a.e.t.) |  Halmstad | 
|---|---|---|
| Wender  34' Žvirgždauskas  103' (o.g.) | Report | Þorvaldsson  15' Žvirgždauskas  89' Ingelsten  113' | 
4–4 on aggregate; Halmstad won on away goals.
| Copenhagen  | 0–1 |  Hamburg | 
|---|---|---|
| Report | Van der Vaart  90+1' (pen.) | 
Hamburg won 2–1 on aggregate.
| Dnipro Dnipropetrovsk  | 5–1 |  Hibernian | 
|---|---|---|
| Nazarenko  1' Shershun  26' Shelayev  39' (pen.) Melaschenko  86', 90+4' | Report | Riordan  25' | 
Dnipro Dnipropetrovsk won 5–1 on aggregate.
| AZ  | 3–1 |  Krylya Sovetov Samara | 
|---|---|---|
| Van Galen  44' Koevermans  79' Landzaat  84' (pen.) | Report | Adamu  15' | 
6–6 on aggregate; AZ won on away goals.
| Dyskobolia Grodzisk  | 2–4 |  Lens | 
|---|---|---|
| Sedláček  57' (pen.) Sáblík  78' | Report | Cousin  23', 54' Dindane  30' Lachor  91' | 
Lens won 5–3 on aggregate.
| Genk .svg.png.webp) | 0–1 |  Litex Lovech | 
|---|---|---|
| Report | Sandrinho  56' | 
Litex Lovech won 3–2 on aggregate.
| Partizan .svg.png.webp) | 2–5 |  Maccabi Petah Tikva | 
|---|---|---|
| Radonjić  13' (pen.), 41' | Report | Mashiah  4' (pen.) Golan  21', 44', 48' Edri  88' | 
Maccabi Petah Tikva won 5–4 on aggregate.
Middlesbrough won 2–0 on aggregate.
Monaco won 5–1 on aggregate.
| Anorthosis Famagusta .svg.png.webp) | 0–4 | .svg.png.webp) Palermo | 
|---|---|---|
| Report | Caracciolo  5' Makinwa  46', 69' Santana  53' | 
Palermo won 6–1 on aggregate.
| Metalurh Donetsk  | 2–2 |  PAOK | 
|---|---|---|
| Kosyrin  39' Shyshchenko  57' | Report | Salpingidis  42' Konstantinidis  45+1' | 
3–3 on aggregate; PAOK won on away goals.
Rennes won 3–1 on aggregate.
Roma won 5–1 on aggregate.
Sevilla won 2–0 on aggregate.
| Debrecen  | 0–2 |  Shakhtar Donetsk | 
|---|---|---|
| Report | Brandão  18' Elano  24' | 
Shakhtar Donetsk won 6–1 on aggregate.
| Lokomotiv Moscow  | 3–2 |  Brann | 
|---|---|---|
| Loskov  61' Asatiani  77' Bilyaletdinov  91' | Report | Macallister  47' Miller  74' | 
Lokomotiv Moscow won 5–3 on aggregate.
| Cork City  | 1–2 |  Slavia Prague | 
|---|---|---|
| O'Callaghan  73' (pen.) | Report | Piták  28' Vlček  59' | 
Slavia Prague won 4–1 on aggregate.
| Galatasaray  | 1–1 |  Tromsø | 
|---|---|---|
| Şükür  79' | Report | Ademolu  32' | 
Tromsø won 2–1 on aggregate.
Steaua București won 6–1 on aggregate.
| Domžale  | 1–0 |  Stuttgart | 
|---|---|---|
| Stevanović  16' | Report | 
Stuttgart won 2–1 on aggregate.
2–2 on aggregate; Viking won on away goals.
Sampdoria won 2–1 on aggregate.
Zenit Saint Petersburg won 1–0 on aggregate.
- Notes
- Note 1: Maccabi Petah Tikva played their home matches at Ramat Gan Stadium in Tel Aviv District instead of their regular stadium, Municipal Stadium, Petah Tikva.
