Iodocholesterol

Iodocholesterol, or 19-iodocholesterol, also as iodocholesterol (131I) (INN) and NP-59, is a derivative of cholesterol with an iodine atom in the C19 position and a radiopharmaceutical.[1][2] When the iodine atom is a radioactive isotope (iodine-125 or iodine-131), it is used as an adrenal cortex radiotracer in the diagnosis of patients suspected of having Cushing's syndrome, hyperaldosteronism,[3] pheochromocytoma, and adrenal remnants following total adrenalectomy.[1][2]

Iodocholesterol
Clinical data
Other namesIodocholesterol; 19-Iodocholesterol; Iodocholesterol (131I); 19-Iodocholest-5-en-3β-ol
ATC code
Identifiers
  • (3S,8S,9S,10S,13R,14S,17R)-10-(iodomethyl)-13-methyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.048.618
Chemical and physical data
FormulaC27H45IO
Molar mass512.560 g·mol−1
3D model (JSmol)
  • CC(C)CCC[C@@H](C)[C@H]3CC[C@H]2[C@@H]4C\C=C1\C[C@@H](O)CC[C@]1(CI)[C@H]4CC[C@@]23C
  • InChI=1S/C27H45IO/c1-18(2)6-5-7-19(3)23-10-11-24-22-9-8-20-16-21(29)12-15-27(20,17-28)25(22)13-14-26(23,24)4/h8,18-19,21-25,29H,5-7,9-17H2,1-4H3/t19-,21+,22+,23-,24+,25+,26-,27-/m1/s1 checkY
  • Key:FIOAEFCJGZJUPW-FTLVODPJSA-N checkY
 ☒NcheckY (what is this?)  (verify)

References
  1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 692–. ISBN 978-1-4757-2085-3.
  2. Clark OH, American Cancer Society (2003). Endocrine Tumors. PMPH-USA. pp. 124–. ISBN 978-1-55009-134-2.
  3. Fischer M, Rosenbach EA, Glaser B, Stokar J (2023-02-24). "NP-59 Scintigraphy for Primary Aldosteronism Lateralization in a Patient With Polycystic Kidney Disease". AACE Clinical Case Reports. 9 (3): 97–98. doi:10.1016/j.aace.2023.02.006. PMC 10213608. PMID 37251975. S2CID 257212197.
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