Lisinopril/hydrochlorothiazide

Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure.[1] It contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic.[1][2] Typically, it becomes an option once a person is doing well on the individual components.[3] It is taken by mouth.[2]

Lisinopril/hydrochlorothiazide
Combination of
LisinoprilACE inhibitor
HydrochlorothiazideThiazide diuretic
Clinical data
Trade namesZestoretic, Prinzide, others
AHFS/Drugs.comMultum Consumer Information
MedlinePlusa601070
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG
  (verify)

Common side effects include dizziness, headache, cough, and feeling tired.[1] Severe side effects may include angioedema and low blood pressure.[1] Use during pregnancy may harm the baby.[1]

The combination was approved for medical use in the United States in 1989.[2] It is on the World Health Organization's List of Essential Medicines.[4] It is available as a generic medication.[3] In 2020, it was the 50th most commonly prescribed medication in the United States, with more than 13 million prescriptions.[5][6]

References
  1. "Zestoretic- lisinopril and hydrochlorothiazide tablet". DailyMed. Retrieved 9 February 2022.
  2. "Hydrochlorothiazide and lisinopril Uses, Side Effects & Warnings". Drugs.com. Cerner Multum. Retrieved 26 December 2018.
  3. British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. 166. ISBN 978-0857112989.
  4. World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  5. "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  6. "Hydrochlorothiazide; Lisinopril - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.


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