ZC3HAV1

ZC3HAV1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X5Y, 4X52
Identifiers
Aliases	ZC3HAV1, ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, zinc finger CCCH-type containing, antiviral 1
External IDs	OMIM: 607312 MGI: 1926031 HomoloGene: 10585 GeneCards: ZC3HAV1
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	139,132,122 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	38,331,538 bp[2]
RNA expression pattern
	Top expressed in
	cancellous bone; ; endothelial cell; ; visceral pleura; ; blood; ; parietal pleura; ; jejunal mucosa; ; pancreatic ductal cell; ; superficial temporal artery; ; bronchial epithelial cell; ; bone marrow;
	Top expressed in
	Paneth cell; ; blood; ; cumulus cell; ; spleen; ; hair follicle; ; bone marrow; ; thymus; ; seminal vesicula; ; jejunum; ; right lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; RNA binding; cadherin binding; NAD+ ADP-ribosyltransferase activity; NAD+ binding; protein ADP-ribosylase activity;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	positive regulation of interferon-alpha production; immune system process; response to virus; positive regulation of mRNA catabolic process; negative regulation of viral genome replication; positive regulation of RIG-I signaling pathway; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response; positive regulation of interferon-beta production; protein poly-ADP-ribosylation; protein ADP-ribosylation;
	Sources:Amigo / QuickGO
Orthologs
	56829
	78781
	ENSG00000105939
	ENSMUSG00000029826
	Q7Z2W4
	Q3UPF5
	NM_020119; NM_024625; NM_001363491
	NM_028421; NM_028864; NM_001347122
	NP_064504; NP_078901; NP_001350420
	NP_001334051; NP_082697; NP_083140
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.[5][6][7]

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and at least four isoform variants have been described.[8][7]

Mechanism of zinc-finger antiviral protein (ZAP) recognition of specific target RNA, and the process by which ZAP coordinates downstream RNA degradation (right). ZAP-RNA complex protein ribbon diagram (left).

References

GRCh38: Ensembl release 89: ENSG00000105939 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029826 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gao G, Guo X, Goff SP (Sep 2002). "Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein". Science. 297 (5587): 1703–6. doi:10.1126/science.1074276. PMID 12215647. S2CID 42188205.
Katoh M, Katoh M (Jul 2003). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31". Int J Oncol. 23 (2): 541–7. doi:10.3892/ijo.23.2.541. PMID 12851707.
"Entrez Gene: ZC3HAV1 zinc finger CCCH-type, antiviral 1".
Ficarelli, Mattia; Neil, Stuart J.D.; Swanson, Chad M. (29 September 2021). "Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System". Annual Review of Virology. 8 (1): 265–283. doi:10.1146/annurev-virology-091919-104213. ISSN 2327-056X. PMID 34129371.

Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Bick MJ, Carroll JW, Gao G, et al. (2003). "Expression of the zinc-finger antiviral protein inhibits alphavirus replication". J. Virol. 77 (21): 11555–62. doi:10.1128/JVI.77.21.11555-11562.2003. PMC 229374. PMID 14557641.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
MacDonald MR, Machlin ES, Albin OR, Levy DE (2007). "The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses". J. Virol. 81 (24): 13509–18. doi:10.1128/JVI.00402-07. PMC 2168828. PMID 17928353.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105939 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029826 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12215647-5] Gao G, Guo X, Goff SP (Sep 2002). "Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein". Science. 297 (5587): 1703–6. doi:10.1126/science.1074276. PMID 12215647. S2CID 42188205.

[pmid12851707-6] Katoh M, Katoh M (Jul 2003). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31". Int J Oncol. 23 (2): 541–7. doi:10.3892/ijo.23.2.541. PMID 12851707.

[entrez-7] "Entrez Gene: ZC3HAV1 zinc finger CCCH-type, antiviral 1".

[Ficarelli-8] Ficarelli, Mattia; Neil, Stuart J.D.; Swanson, Chad M. (29 September 2021). "Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System". Annual Review of Virology. 8 (1): 265–283. doi:10.1146/annurev-virology-091919-104213. ISSN 2327-056X. PMID 34129371.

ZC3HAV1

References

Further reading