Eternal youth

Eternal youth is the concept of human physical immortality free of ageing. The youth referred to is usually meant to be in contrast to the depredations of aging, rather than a specific age of the human lifespan. Eternal youth is common in mythology, and is a popular theme in fiction.

Not to be confused with Truth serum.
Youth and Time, John William Godward, 1901

Religion and mythology

Eternal youth is a characteristic of the inhabitants of Paradise in Abrahamic religions.

The Hindus believe that the Vedic and the post-Vedic rishis have attained immortality, which implies the ability to change one's body's age or even shape at will. These are some of the siddhas in Yoga. Markandeya is said to always stay at the age of 16.

The difference between eternal life and the more specific eternal youth is a recurrent theme in Greek and Roman mythology. The mytheme of requesting the boon of immortality from a god, but forgetting to ask for eternal youth appears in the story of Tithonus. A similar theme is found in Ovid regarding the Cumaean Sibyl.

In Norse mythology, Iðunn is described as providing the gods apples that grant them eternal youthfulness in the 13th-century Prose Edda.

Telomeres

An individual's DNA plays a role in the aging process. Aging begins even before birth, as soon as cells start to die and need to be replaced. On the ends of each chromosome are repetitive sequences of DNA, telomeres, that protect the chromosome from joining with other chromosomes, and have several key roles. One of these roles is to regulate cell division by allowing each cell division to remove a small amount of genetic code. The amount removed varies by the cell type being replicated. The gradual degradation of the telomeres restricts cell division to 40-60 times, also known as the Hayflick limit. Once this limit has been reached, more cells die than can be replaced in the same time span. Thus, soon after this limit is reached the organism dies. The importance of telomeres is now clearly evident: lengthen the telomeres, lengthen the life.[1]

However, a study of the comparative biology of mammalian telomeres indicated that telomere length correlates inversely, rather than directly, with lifespan, and concluded that the contribution of telomere length to lifespan remains controversial.[2] Also, telomere shortening does not occur with age in some postmitotic tissues, such as in the rat brain.[3] In humans, skeletal muscle telomere lengths remain stable from ages 23–74.[4] In baboon skeletal muscle, that consists of fully differentiated post-mitotic cells, less than 3% of myonuclei contain damaged telomeres and this percentage does not increase with age.[5] Thus telomere shortening does not appear to be a major factor in the aging of the differentiated cells of brain or skeletal muscle.

Studies have shown that 90 percent of cancer cells contain large amounts of an enzyme called telomerase.[6] Telomerase is an enzyme that replenishes the worn away telomeres by adding bases to the ends and thus renewing the telomere. A cancer cell has in essence turned on the telomerase gene, and this allows them to have an unlimited amount of divisions without the telomeres wearing away. Other kinds of cells that can surpass the Hayflick limit are stem cells, hair follicles, and germ cells.[7] This is because they contain raised amounts of telomerase.

Therapy

The idea that the human body can be repaired in old age to a more youthful state has gathered significant commercial interest over the past few years, including by companies such as Human Longevity Inc, Google Calico, and Elysium Health.[8][9][10] In addition to these larger companies, many startups are currently developing therapeutics to tackle the 'ageing problem' using therapy.[11][12] In 2015 a new class of drugs senolytics was announced (currently in pre-clinical development) designed specifically to combat the underlying biological causes of frailty.[13]

Philanthropy

The "loss of youth" or ageing process is responsible for increasing the risk of individuals to many diseases including cancer, Parkinson's, Alzheimer's, and others. As a result, in recent years, many high net worth individuals have donated large amounts of their money towards initiatives towards scientific research into the ageing process itself or therapies to slow or reverse the ageing process.[14] These people include Jeff Bezos, Ray Kurzweil, Peter Thiel,[15] Aubrey de Grey, Larry Ellison, Sergey Brin, Dmitry Itskov, Paul Gallen,[16] and Mark Zuckerberg.[17]

See also

References
  1. Lee J. Siegel. "ARE TELOMERES THE KEY TO AGING AND CANCER?". Archived from the original on 2013-01-20.
  2. Gomes NM, Ryder OA, Houck ML, Charter SJ, Walker W, Forsyth NR, Austad SN, Venditti C, Pagel M, Shay JW, Wright WE (2011). "Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination". Aging Cell. 10 (5): 761–768. doi:10.1111/j.1474-9726.2011.00718.x. PMC 3387546. PMID 21518243.
  3. Cherif H, Tarry JL, Ozanne SE, Hales CN (2003). "Ageing and telomeres: a study into organ- and gender-specific telomere shortening". Nucleic Acids Res. 31 (5): 1576–1583. doi:10.1093/nar/gkg208. PMC 149817. PMID 12595567.
  4. Renault V, Thornell LE, Eriksson PO, Butler-Browne G, Mouly V (2003). "Regenerative potential of human skeletal muscle during aging". Aging Cell. 1 (2): 132–139. doi:10.1046/j.1474-9728.2002.00017.x. PMID 12882343. S2CID 7020102.
  5. Jeyapalan JC, Ferreira M, Sedivy JM, Herbig U (2007). "Accumulation of senescent cells in mitotic tissue of aging primates". Mech Ageing Dev. 128 (1): 36–44. doi:10.1016/j.mad.2006.11.008. PMC 3654105. PMID 17116315.
  6. Klaus Damm (2001). "A highly selective telomerase inhibitor limiting human cancer cell proliferation". The EMBO Journal. 20 (24): 6958–6968. doi:10.1093/emboj/20.24.6958. PMC 125790. PMID 11742973.
  7. Peter J. Hornsby (2007). "Telomerase and the aging process". Experimental Gerontology. 42 (7): 575–81. doi:10.1016/j.exger.2007.03.007. PMC 1933587. PMID 17482404.
  8. "Former unicorn genetics startup Human Longevity loses its horn". 2018-12-11. Retrieved December 26, 2018.
  9. "Google's Long, Strange Life-Span Trip". Retrieved December 26, 2018.
  10. "The Anti-Aging Pill". Retrieved December 26, 2018.
  11. "Esthechoc: Scientists invent 'anti-ageing' chocolate".
  12. "Startup Alkahest inks a $50M deal for anti-aging R&D".
  13. "New "Senolytic" Drugs Can Dramatically Increase Healthy Lifespan". 11 March 2015.
  14. Wallace, Benjamin (August 23, 2016). "An MIT Scientist Claims That This Pill Is the Fountain of Youth". New York Magazine.
  15. "Billionaire Peter Thiel embarks on anti-aging crusade".
  16. "These Tech Billionaires Are Determined to Buy Their Way Out of Death". Business Insider.
  17. "Zuckerberg, Brin join forces to extend life". February 20, 2013. Retrieved August 8, 2016.
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