2008 United States presidential election in Wyoming

• 2008 Wyoming Democratic presidential caucuses
• 2008 Wyoming Republican presidential caucuses

Voting taking place in a Laramie, Wyoming polling station

Located in the Inner Mountain West, Wyoming was home to then-incumbent Vice President Dick Cheney. It is one of the most reliably Republican states in the nation—and by some measures, the most Republican. Its demographics are a perfect fit for the Republican Party. It is the least populated state in the nation (even less than the District of Columbia), has no major metropolitan areas, and is heavily rural and White/Caucasian. Voters in the state tend to be very conservative on both social and fiscal issues. At the time of this election, however, it did still have a Democratic governor. No Democratic presidential nominee has won Wyoming since Lyndon B. Johnson in his landslide election in 1964—one of only eight times the state has voted Democrat in a presidential election.

Republicans have several structural advantages in the state. Large chunks of Wyoming are located in out-of-state television markets—most notably Denver and Salt Lake City. This forces statewide candidates to advertise in areas where most of their audience can't vote for them. Additionally, 60 percent of the state's registered voters are Republicans while only 25 percent are Democrats—one of the largest discrepancies in the nation.

The 2008 election was no different. The state was called for McCain as soon as the polls closed, and gave McCain his second largest margin of victory in 2008. McCain carried Laramie County, the most populous county that contains the state capital and largest city of Cheyenne, with 58.98 percent of the vote as well as every other county throughout the state often by more than two-to-one margins but two. Obama greatly improved upon Kerry's performance in Teton County, the most affluent county in Wyoming that includes the Jackson Hole prime ski resort and tourism attractions such as Yellowstone National Park and Grand Teton National Park, carrying the county with 60.67% of the vote. Obama also won Albany County, due in large part to the presence of the University of Wyoming at Laramie and the tremendous excitement that his campaign fueled among younger voters and college students. The county would return to its Republican roots in 2012 and 2016, but flipped to Obama's former running mate Joe Biden in 2020, the only county to do so.

With 64.78% of the popular vote, Wyoming would prove to be McCain's second strongest state in the 2008 election after Oklahoma.[18]

During the same election, incumbent Republican U.S. Senator Mike Enzi was reelected in a landslide victory over Democrat Chris Rothfuss, a professor of political science at the University of Wyoming. Enzi received 75.63% of the vote while Rothfuss took in 24.26%. For the state's other U.S. Senate seat's special election, incumbent Republican John Barrasso was also elected in a landslide with 73.35% of the vote over Democratic attorney Nick Carter of Gillette who received 26.53%. The state's sole seat in the United States House of Representatives was also up for grabs, with incumbent Republican U.S. Representative Barbara Cubin retiring. Former State Treasurer Cynthia Lummis, a Republican, defeated Democrat Gary Trauner and Libertarian W. David Herbert for the at-large seat. Lummis received 52.62% of the vote to Trauner's 42.81% and Herbert's 4.42%. Democrats did have success at the state level, however, as they picked up two seats in the Wyoming House of Representatives.

Technically the voters of Wyoming cast their ballots for electors: representatives to the Electoral College. Wyoming is allocated 3 electors because it has 1 congressional districts and 2 senators. All candidates who appear on the ballot or qualify to receive write-in votes must submit a list of 3 electors, who pledge to vote for their candidate and his or her running mate. Whoever wins the majority of votes in the state is awarded all 3 electoral votes. Their chosen electors then vote for president and vice president. Although electors are pledged to their candidate and running mate, they are not obligated to vote for them.[19] An elector who votes for someone other than his or her candidate is known as a faithless elector.

The electors of each state and the District of Columbia met on December 15, 2008, to cast their votes for president and vice president. The Electoral College itself never meets as one body. Instead the electors from each state and the District of Columbia met in their respective capitols.

The following were the members of the Electoral College from the state. All 3 were pledged to John McCain and Sarah Palin:[20]

1. Rosa Goolsby
2. Ron Micheli
3. Susan Thomas

• United States presidential elections in Wyoming
• Presidency of Barack Obama