UDP-glucose—hexose-1-phosphate uridylyltransferase
In enzymology, an UDP-glucose—hexose-1-phosphate uridylyltransferase (EC 2.7.7.12) is an enzyme that catalyzes the chemical reaction
- UDP-glucose + alpha-D-galactose 1-phosphate alpha-D-glucose 1-phosphate + UDP-galactose
| UDP-glucose:hexose-1-phosphate uridylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Galactose-1-phosphate uridylyltransferase homodimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.7.12 | ||||||||
| CAS no. | 9026-21-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are UDP-glucose and alpha-D-galactose 1-phosphate, whereas its two products are alpha-D-glucose 1-phosphate and UDP-galactose.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase. Other names in common use include uridyl transferase, hexose-1-phosphate uridylyltransferase, uridyltransferase, and hexose 1-phosphate uridyltransferase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1HXQ, 2H39, 2Q4H, and 2Q4L.
References
- KALCKAR HM, BRAGANCA B, MUNCH-PETERSEN HM (1953). "Uridyl transferases and the formation of uridine diphosphogalactose". Nature. 172 (4388): 1038. doi:10.1038/1721038a0. PMID 13111247. S2CID 4273742.
- KURAHASHI K, SUGIMURA A (1960). "Purification and properties of galactose 1-phosphate uridyl transferase from Escherichia coli". J. Biol. Chem. 235: 940–6. PMID 14412847.
- Mayes JS; Hansen RG (1966). "Galactose 1-phosphate uridyl transferase". Methods Enzymol. 9: 708–713. doi:10.1016/0076-6879(66)09143-2.
- Saito S, Ozutsumi M, Kurahashi K (1967). "Galactose 1-phosphate uridylyltransferase of Escherichia coli. II Further purification and characterization". J. Biol. Chem. 242 (10): 2362–8. PMID 5338129.
- SMITH EE, MILLS GT (1955). "The uridyl transferase of mammary gland". Biochim. Biophys. Acta. 18 (1): 152. doi:10.1016/0006-3002(55)90029-9. PMID 13260264.